Batchu et al determine whether generating melanoma antigen family A, 3 (MAGE-A3), a tumor-specific cancer-testis antigen, as a fusion protein with cell-penetrating domain will enhance the cytosolic bioavailability of MAGE-A3. Berger provides discussion in a related Invited Commentary.
Huang et al investigate the association between levels of hepatitis B surface antigen (HBsAg) and the risk for tumor recurrence after curative surgery for hepatocellular carcinoma (HCC) in patients with low levels of hepatitis B virus DNA.
This prospective cohort study examines the genetic and epigenetic events associated with follicular thyroid hyperplasia.
Chaturvedi et al tested the hypothesis that teduglutide impairs human intestinal epithelial differentiation. Caco-2 cells were treated with 0 to 1000nM teduglutide for 72 hours. The cell cycle was analyzed by bromodeoxyuridine incorporation or propidium iodide staining and flow cytometry, and cell proliferation was measured by MTS tetrazolium dye assay.
In a randomized controlled experiment, Kovalenko and Basson determine whether schlafen 3 (but not other schlafen proteins) act in vivo and whether its effects are limited to the small intestine.