This clinical trial analyzes the feasibility and clinical benefit of intraoperative near infrared fluorescence sentinel lymph node excision (SLNE) compared with standard technetium Tc 99m–guided SLNE in 80 patients with malignant melanoma on the trunk or extremities.
Findings from this retrospective review show the importance of removing the less radioactive nodes in patients with cutaneous melanoma.
Kitano and colleagues describe 2 cases of melanoma of the appendix presenting with appendicitis and review their institutional experience with this entity.
Riccardo et al investigated the distribution of the number of excised lymph nodes in a large patient series to identify values that may serve as benchmarks for monitoring the quality of lymphadenectomy in patients with melanoma.
Batchu et al determine whether generating melanoma antigen family A, 3 (MAGE-A3), a tumor-specific cancer-testis antigen, as a fusion protein with cell-penetrating domain will enhance the cytosolic bioavailability of MAGE-A3. Berger provides discussion in a related Invited Commentary.
Leung et al reviewed the records of patients with cutaneous melanoma who underwent completion lymph node dissection to evaluate whether disease limited to sentinel lymph nodes represents different clinical significance than disease spread into nonsentinel lymph nodes. See the invited commentary by Leong.