This article examines fluorescent labeling of tumor cells during surgery and its impact on intraoperative detection of cancer cells.
This cohort study reports that the extent of lymphadenectomy during surgery for esophageal cancer is not associated with 5-year all-cause or disease-specific survival.
This case series assesses the efficacy of liver transplantation in children with advanced hepatocellular carcinoma or hepatoblastoma.
This cohort study explores the effect of radial margin positivity on perioperative outcomes as well as survival and disease-free survival in colon cancer.
This nationwide cohort study defines stage-specific treatments and prognosis of colon cancer diagnosed in young adults (ages 18-49 years) vs older adults (ages 65-75 years).
This retrospective cohort study finds that conditional disease-free survival improves over time following resection of gastrointestinal stromal tumors. See the Invited Commentary by Maker.
This retrospective review shows that most patients with stage IV colorectal cancer had undergone primary tumor resection but, beginning in 2001, a trend toward fewer resections was seen. Despite the decreasing resection rate, patient survival rates improved.
This randomized clinical trial shows that education and provision of incentive spirometry for unmonitored patient use does not result in statistically significant improvement in pulmonary dynamics following laparotomy.
This database analysis found that approximately one-fourth of patients undergoing initial breast conservation surgery for breast cancer will have a subsequent operative intervention. See also the Invited Commentary by Margenthaler and Vaughan.
This retrospective cohort study reports that implementation of a multidisciplinary hepatopancreaticobiliary surgical program leads to regionalization of care and improved quality of cancer care and surgical outcomes.
Parvanescu et al assess the prevalence of polyostotic fibrous dysplasia and McCune-Albright syndrome among patients operated on for presumptive sporadic intraductal papillary mucinous neoplasms. Systematic screening of 272 patients revealed 1 patient with imaging and café au lait spots suggestive of McCune-Albright syndrome.
Riccardo et al investigated the distribution of the number of excised lymph nodes in a large patient series to identify values that may serve as benchmarks for monitoring the quality of lymphadenectomy in patients with melanoma.
Huang et al investigate the association between levels of hepatitis B surface antigen (HBsAg) and the risk for tumor recurrence after curative surgery for hepatocellular carcinoma (HCC) in patients with low levels of hepatitis B virus DNA.
Mavros et al conduct a systematic review and meta-analysis to evaluate the available evidence regarding treatment and prognosis in patients with intrahepatic cholangiocarcinoma.
Hyder and coauthors combine clinicopathologic variables associated with overall survival after resection of intrahepatic cholangiocarcinoma into a prediction nomogram.
Batchu et al determine whether generating melanoma antigen family A, 3 (MAGE-A3), a tumor-specific cancer-testis antigen, as a fusion protein with cell-penetrating domain will enhance the cytosolic bioavailability of MAGE-A3. Berger provides discussion in a related Invited Commentary.
Gall et al examine the impact of 2 different surgical techniques, standard pancreaticoduodenectomy and no-touch isolation pancreaticoduodenectomy, on tumor behavior and outcome in patients with pancreatic cancer by using circulating tumor cells as biomarkers.
Goudardet al describe a large single-center experience with central pancreatectomy. See also the invited commentary by Del Chiaro.
Kadera and colleagues aimed to perform a detailed survival analysis of their institution’s experience with patients with locally advanced/borderline resectable pancreatic ductal adenocarcinoma who were downstaged and underwent surgical resection and (2) identify prognostic biomarkers that may help guide a decision for the use of adjuvant therapy in this patient subgroup. L. Andrew DiFronzo, MD, provided an invited commentary.