This study of medical records in a prospectively maintained database identifies factors associated with survival in patients with periampullary adenocarcinomas and compares survival between those having intestinal-type or pancreaticobiliary-type cancers originating from the duodenum, ampulla, or distal common bile duct with those having pancreatic ductal adenocarcinoma.
Batchu et al determine whether generating melanoma antigen family A, 3 (MAGE-A3), a tumor-specific cancer-testis antigen, as a fusion protein with cell-penetrating domain will enhance the cytosolic bioavailability of MAGE-A3. Berger provides discussion in a related Invited Commentary.
Bagaria et al use as an example the triple-negative phenotype defined by the absence of estrogen
receptor, progesterone receptor, and human epidermal growth factor 2 to examine whether such
inclusion improves the prognostic accuracy of TNM staging for breast cancer.
This study compares the characteristics and outcomes among liver transplant recipients with radiographically apparent hepatocellular carcinoma lesions with α-fetoprotein (AFP)–producing tumors with those of recipients with tumors that do not produce AFP.
Gangi et al compare the outcomes of breast-conserving therapy for patients with triple-negative breast cancer (TNBC) with those of patients with non-TNBC subtypes, specifically luminal A, luminal B, and v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2) enriched.
In a randomized controlled experiment, Kovalenko and Basson determine whether schlafen 3 (but not other schlafen proteins) act in vivo and whether its effects are limited to the small intestine.