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  • Lessons From McCune-Albright Syndrome–Associated Intraductal Papillary Mucinous Neoplasms: : GNAS -Activating Mutations in Pancreatic Carcinogenesis

    Abstract Full Text
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    JAMA Surg. 2014; 149(8):858-862. doi: 10.1001/jamasurg.2014.535

    Parvanescu et al assess the prevalence of polyostotic fibrous dysplasia and McCune-Albright syndrome among patients operated on for presumptive sporadic intraductal papillary mucinous neoplasms. Systematic screening of 272 patients revealed 1 patient with imaging and café au lait spots suggestive of McCune-Albright syndrome.

  • JAMA Surgery

    Figure: Radiological Examination

    A, Radiological workup with bone window 3-dimensional computed tomography reconstruction shows polyostotic fibrous dysplasia, including axial and peripheral involvement. B, Preoperative enhanced portal-phase abdominal computed tomography image obtained through the mid-part of the pancreas shows a heterogeneous 11-cm duodenal infiltrating pancreatic mass, with biliary and pancreatic duct dilatation.

    Abstract Full Text
    Arch Surg. 1938; 36(5):874-898. doi: 10.1001/archsurg.1938.01190230153012