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Implant Radiation Therapy for Carcinoma of the Pancreas

AMA Arch Surg. 1958;77(4):613-620. doi:10.1001/archsurg.1958.04370010145014.
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An increasing number of five-year survivals following radical surgical treatment of carcinoma of the head of the pancreas are appearing in the literature,1 so that serious consideration must be given to this form of treatment in favorable cases. However, unfavorable or technically inoperable cases probably still constitute the majority of carcinomas in this region as they are encountered clinically, and for this group of cases we must seek other forms of therapy. Treatment in these cases has been limited for the most part to bypass operations to remove obstruction. Radiation therapy for these inoperable tumors has been attempted with some success where local implant therapy was used with radium or radon, with or without external irradiation.2 There are, however, certain severe limitations in this approach in that the radioactive sources must be available at the time of operation, the operator must accept substantial radiation exposure during the procedure, and the


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