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Special Feature |

Image of the Month—Diagnosis FREE

Arch Surg. 2011;146(7):884. doi:10.1001/archsurg.2011.165-b.
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Published online

Solitary fibrous tumor (SFT) is a rare mesenchymal tumor with a highly variable clinical presentation. Extrathoracic SFT carries a malignant potential of 11% to 33%1,2 and should be managed with surgical resection if possible. Based on a small number of reported cases, pelvic SFT is generally believed to be clinically comparable with those in other extrathoracic locations. They represent a diagnostic challenge to the surgeon because they are easily mistaken for other more common tumor types based on imaging studies.3 In addition, pelvic SFT may present with more advanced tumor size and carry a higher rate of pathologic malignancy.4

In a case report that reviewed all 17 reported pelvic SFT cases to date, Kawamura and colleagues4 noted a malignancy rate of 25%, slightly higher than the malignancy rate reported for other extrathoracic SFTs.1 In addition, the clinical behavior of extrathoracic SFTs is unfortunately not predictable based on pathology. While there are a number of pathologic features reported to roughly correlate with malignancy, including size of the tumor, hypercellularity, mitotic activity, nuclear pleomorphism, necrosis, and Ki-67 and p53 staining,1,5,6 none of these are reliable markers for recurrence and metastasis.7,8 It follows therefore that in our case, as in all cases of pelvic SFT, even in those without malignant features in the pathology, patients should be followed up closely for any clinical or radiological signs of recurrence.

Extrathoracic SFT is often confused on radiographic imaging with other more common tumors.9,10 In this case, based on the size, vascularity, and location noted on computed tomographic imaging, the mass was presumed to be a paraganglioma arising from the organ of Zuckerkandl. This assumption did not adversely affect the overall management, which would have required surgical resection regardless.

In summary, we report a case of pelvic SFT with benign pathological features that was initially thought to be a paraganglioma on radiographic imaging. This is one of only a handful of reports in which this tumor type originates in the pelvis. Because of the inherent malignant potential, more cases with long-term follow-up will be needed to help identify characteristics that predict aggressive behavior. Accordingly, surgeons should have a higher degree of suspicion for this tumor type in patients who present with large pelvic masses.

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Correspondence: Joshua Wolf, MD, Johns Hopkins Hospital, Department of Surgery, 600 N Wolfe St, Blalock 655, Baltimore, MD 21287 (jwolf8@jhmi.edu).

Accepted for Publication: April 10, 2010.

Author Contributions:Study concept and design: Marohn. Acquisition of data: Wolf, Koehler, and Fishman. Analysis and interpretation of data: Nguyen and Koehler. Drafting of the manuscript: Wolf. Critical revision of the manuscript for important intellectual content: Nguyen, Koehler, Fishman, and Marohn. Administrative, technical, and material support: Wolf, Nguyen, Fishman, and Marohn.

Financial Disclosure: None reported.

Hasegawa T, Matsuno Y, Shimoda T, Hasegawa F, Sano T, Hirohashi S. Extrathoracic solitary fibrous tumors: their histological variability and potentially aggressive behavior.  Hum Pathol. 1999;30(12):1464-1473
PubMed   |  Link to Article
Cranshaw IM, Gikas PD, Fisher C, Thway K, Thomas JM, Hayes AJ. Clinical outcomes of extra-thoracic solitary fibrous tumours.  Eur J Surg Oncol. 2009;35(9):994-998
PubMed   |  Link to Article
Joe BN, Bolaris M, Horvai A, Yeh BM, Coakley FV, Meng MV. Solitary fibrous tumor of the male pelvis: findings at CT with histopathologic correlation.  Clin Imaging. 2008;32(5):403-406
PubMed   |  Link to Article
Kawamura S, Nakamura T, Oya T,  et al.  Advanced malignant solitary fibrous tumor in pelvis responding to radiation therapy.  Pathol Int. 2007;57(4):213-218
PubMed   |  Link to Article
Vallat-Decouvelaere AV, Dry SM, Fletcher CD. Atypical and malignant solitary fibrous tumors in extrathoracic locations: evidence of their comparability to intra-thoracic tumors.  Am J Surg Pathol. 1998;22(12):1501-1511
PubMed   |  Link to Article
Yokoi T, Tsuzuki T, Yatabe Y,  et al.  Solitary fibrous tumour: significance of p53 and CD34 immunoreactivity in its malignant transformation.  Histopathology. 1998;32(5):423-432
PubMed   |  Link to Article
Trastour C, Piche M, Bafghi A, Checchi-Guichard C, Bongain A. Solitary fibrous tumor of the pelvis.  Eur J Obstet Gynecol Reprod Biol. 2006;124(2):254-255
PubMed   |  Link to Article
Yoshida R, Takada H, Iwamoto S,  et al.  A solitary fibrous tumor in the perianal region with a 13-year follow-up: report of a case.  Surg Today. 1999;29(7):642-645
PubMed   |  Link to Article
Ishikawa T, Kawabata G, Terakawa T, Kamidono S, Fujisawa M. Solitary fibrous tumor in the pelvic space.  Urol Res. 2004;32(1):49-50
PubMed   |  Link to Article
Wat SY, Sur M, Dhamanaskar K. Solitary fibrous tumor (SFT) of the pelvis.  Clin Imaging. 2008;32(2):152-156
PubMed   |  Link to Article

Figures

Tables

References

Hasegawa T, Matsuno Y, Shimoda T, Hasegawa F, Sano T, Hirohashi S. Extrathoracic solitary fibrous tumors: their histological variability and potentially aggressive behavior.  Hum Pathol. 1999;30(12):1464-1473
PubMed   |  Link to Article
Cranshaw IM, Gikas PD, Fisher C, Thway K, Thomas JM, Hayes AJ. Clinical outcomes of extra-thoracic solitary fibrous tumours.  Eur J Surg Oncol. 2009;35(9):994-998
PubMed   |  Link to Article
Joe BN, Bolaris M, Horvai A, Yeh BM, Coakley FV, Meng MV. Solitary fibrous tumor of the male pelvis: findings at CT with histopathologic correlation.  Clin Imaging. 2008;32(5):403-406
PubMed   |  Link to Article
Kawamura S, Nakamura T, Oya T,  et al.  Advanced malignant solitary fibrous tumor in pelvis responding to radiation therapy.  Pathol Int. 2007;57(4):213-218
PubMed   |  Link to Article
Vallat-Decouvelaere AV, Dry SM, Fletcher CD. Atypical and malignant solitary fibrous tumors in extrathoracic locations: evidence of their comparability to intra-thoracic tumors.  Am J Surg Pathol. 1998;22(12):1501-1511
PubMed   |  Link to Article
Yokoi T, Tsuzuki T, Yatabe Y,  et al.  Solitary fibrous tumour: significance of p53 and CD34 immunoreactivity in its malignant transformation.  Histopathology. 1998;32(5):423-432
PubMed   |  Link to Article
Trastour C, Piche M, Bafghi A, Checchi-Guichard C, Bongain A. Solitary fibrous tumor of the pelvis.  Eur J Obstet Gynecol Reprod Biol. 2006;124(2):254-255
PubMed   |  Link to Article
Yoshida R, Takada H, Iwamoto S,  et al.  A solitary fibrous tumor in the perianal region with a 13-year follow-up: report of a case.  Surg Today. 1999;29(7):642-645
PubMed   |  Link to Article
Ishikawa T, Kawabata G, Terakawa T, Kamidono S, Fujisawa M. Solitary fibrous tumor in the pelvic space.  Urol Res. 2004;32(1):49-50
PubMed   |  Link to Article
Wat SY, Sur M, Dhamanaskar K. Solitary fibrous tumor (SFT) of the pelvis.  Clin Imaging. 2008;32(2):152-156
PubMed   |  Link to Article

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