Accepted for Publication: July 21, 2011.
Author Contributions: Drs Chopra, Sussman, Greene, and Eagle had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Chopra, Eagle, and Saint. Acquisition of data: Chopra, Wesorick, and Eagle. Analysis and interpretation of data: Chopra, Wesorick, Sussman, Greene, Rogers, Froehlich, Eagle, and Saint. Drafting of the manuscript: Chopra. Critical revision of the manuscript for important intellectual content: Chopra, Wesorick, Sussman, Greene, Rogers, Froehlich, Eagle, and Saint. Statistical analysis: Chopra, Sussman, Greene, and Rogers. Administrative, technical, and material support: Chopra, Sussman, Froehlich, and Eagle. Study supervision: Froehlich, Eagle, and Saint.
Financial Disclosure: Dr Froehlich has been a consultant for sanofi-adventis, Ortho-McNeil, and Merck and has received research grants from sanofi-adventis, Blue Cross/Blue Shield of Michigan, Mardigian Foundation, and Fibromuscular Disease Society of America.
Funding/Support: Dr Chopra is supported by a Clinical and Translational Science Award from the Michigan Institute for Clinical and Health Research.
Additional Contributions: Paul Grant, MD, assisted with editing the manuscript, and Andy Hickner, MSI, contributed to the serial literature searches. We thank Charalambos Antoniades, MD; Raitany Almeida, MD; Carlos Caorsi, MD; Sanne E. Hoeks, MSc; Don Poldermans, MD, PhD; Olaf Schouten, MD, PhD; and Young Bin Song, MD, for providing additional, unpublished data for these analyses.