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Invited Critique | Oct 2012 ONLINE FIRST

The Heat of the Matter: Comment on “Initial Experience With Hyperthermic Intraperitoneal Chemotherapy”

Nita Ahuja, MD

Arch Surg. 2012;147(10):924. doi:10.1001/archsurg.2012.1292.

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Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) is being increasingly offered for treatment of peritoneal carcinomatosis. Recent data on colorectal cancer from several large retrospective multicenter trials¹^- 2 and a prospective randomized trial³ have shown promising overall survival, with 5-year survival approaching 40% in patients with complete cytoreduction. Cytoreductive surgery and HIPEC are delivered as a package deal with the concept of complete cytoreductive surgery to remove all macroscopic peritoneal disease followed by HIPEC to treat the microscopic disease burden. However, there remains persistent concern among the oncologic community about the morbidity and mortality of the procedure. The article by Turrini et al⁴ is a well-timed study showing that cytoreductive surgery and HIPEC can be performed with low mortality and acceptable morbidity by an experienced, high-volume team.

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Ahuja N. The Heat of the Matter: Comment on “Initial Experience With Hyperthermic Intraperitoneal Chemotherapy”. Arch Surg. 2012;147(10):924. doi:10.1001/archsurg.2012.1292.

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