0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Invited Critique | ONLINE FIRST

Hyperoxia and Traumatic Brain Injury:  Comment on “Early Hyperoxia Worsens Outcomes After Traumatic Brain Injury”

H. Gill Cryer, MD, PhD
Arch Surg. 2012;147(11):1046. doi:10.1001/archsurg.2012.1641.
Text Size: A A A
Published online

Extract

Brenner and colleagues1 have nicely shown that average PaO2 levels of less than 100 mm Hg or greater than 200 mm Hg are independently associated with higher mortality and worse discharge Glasgow Coma Scale scores in 1547 patients with a brain Abbreviated Injury Score of 3 or greater after risk adjusting for mechanism of injury, age, Injury Severity Score, sex, and admission Glasgow Coma Scale score. It has been well established that hypoxia is detrimental to outcome in brain injury. Because of this, there may be a tendency to give higher levels of oxygen to prevent hypoxia. Indeed, the authors found that 43% of their patients had PaO2 values greater than 200 mm Hg in the first 24 hours of care. Unfortunately, this hyperoxia appears to be detrimental to outcome compared with normoxia and is just as bad as hypoxia. If true, these are important findings that could change the way we approach patients with traumatic brain injury.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();