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Special Feature |

Image of the Month—Diagnosis FREE

[+] Author Affiliations

SECTION EDITOR: CARL E. BREDENBERG, MD

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Arch Surg. 2012;147(7):679-680. doi:10.1001/archsurg.147.7.679-b.
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This patient has undergone coronary artery bypass surgery through midline sternotomy. The lower part of the scar is seen in the photograph. Note that the keloid formation involves the scar in its entirety. However, the lower part of the scar below the lesion has no keloid. Marjolin ulcers usually occur in chronic burns scar ulceration, but such occurrences have also been reported in breasts.1 However, in this patient, the midline scar had healed well with no ulceration. Squamous and basal cell carcinomas have been reported in midline sternotomy scars.24 Basal cell carcinomas are typically slow growing and burrowing, and they would rarely if ever spread to nodes. On the other hand, the poor vascularity and elasticity of scar tissue may render the area more susceptible to carcinogens.4

On close observation of the computed tomographic scan, the lesion is more evident on the right side involving the breast tissue. In addition, the confirmatory evidence would be the histopathology. Note the early glandular formation in Figure 2A. This led to further studies with immunohistochemistry. Positive staining for CK7 and CK20 indicated epithelial origin. However, immunostaining with gross cystic disease fluid protein confirmed the diagnosis of breast cancer. Mammaglobin is a more sensitive marker than gross cystic disease fluid protein, while the latter is more specific.5 In addition, the tumor was positive for estrogen and progesterone receptors and negative for HER2/neu.

Place holder to copy figure label and caption
Graphic Jump Location

Figure 2. Hematoxylin-eosin and immunohistochemisty-positive stainings. A, Hematoxylin-eosin staining of a biopsy showing pleomorphic cells in clusters and cords infiltrating the stroma, suggesting the possibility of a moderately differentiated carcinoma. B, Immunohistochemistry-positive staining for CK7. C, Immunohistochemistry-positive staining for CK20. D, Immunohistochemistry-positive staining for gross cystic disease fluid protein. Original magnification ×100 (A-D).

Breast cancer developing in a preexisting scar is rare and reports are anecdotal. There are reports of breast cancer arising from surgical site scars occurring as a result of breast biopsies, lumpectomies, and abscess drainages.68 In addition, there are reports of breast cancer arising in thoracotomy scars if it were to traverse through the breast.6,7 This should be considered a midline breast cancer developing from the previous sternotomy scar, which would then explain the central location and bilateral nodal disease. In this case, the possibility of breast cancer arising from 1 side (probably right) and crossing midline is less likely because the scar tissue would act as a barrier, at least temporarily. However, this could be considered a less likely but alternative possibility wherein the disease developing in the medial part of the breast near the midline has become locally advanced. The patient was scheduled to undergo neo-adjuvant chemotherapy followed by surgery and radiation.

Return to Quiz Case.

Submissions

The Editor welcomes contributions to the Image of the Month. Manuscripts should be submitted via our online manuscript submission and review system (http://manuscripts.archsurg.com). Articles and photographs accepted will bear the contributor's name. Manuscript criteria and information are per the Instructions for Authors for Archives of Surgery (http://archsurg.ama-assn.org/misc/ifora.dtl). No abstract is needed, and the manuscript should be no more than 3 typewritten pages. There should be a brief introduction, 1 multiple-choice question with 4 possible answers, and the main text. No more than 2 photographs should be submitted. There is no charge for reproduction and printing of color illustrations.

Correspondence: K. Harish, MS, MCh, Department of Surgical Oncology, Curie Centre of Oncology, M. S. Ramaiah Medical College, New Bel Rd, Gokula, Bangalore 560010, India (drkhari@yahoo.com).

Accepted for Publication: July 11, 2011.

Author Contributions:Study concept and design: Harish. Acquisition of data: Madhu. Analysis and interpretation of data: Harish. Drafting of the manuscript: Madhu. Critical revision of the manuscript for important intellectual content: Harish. Administrative, technical, and material support: Harish and Madhu. Study supervision: Harish.

Financial Disclosure: None reported.

Gatto A, Sebastiani S, Falvo L, Giustiniani C, La Rovere C. A rare case of aggressive squamous-cell carcinoma of the breast skin: Marjolin's ulcer: a case report.  Chir Ital. 2008;60((4)):577-582
PubMed
Lau YS, Banwell PE, Pay AD. Basal cell carcinoma arising in scars: late presentation 16 years after a midline sternotomy.  Plast Reconstr Surg. 2004;113((4)):1297-1299
PubMed
Korula R, Hughes CF. Squamous cell carcinoma arising in a sternotomy scar.  Ann Thorac Surg. 1991;51((4)):667-669
PubMed   |  Link to Article
Dolan OM, Lowe L, Orringer MB, Rinek M, Johnson TM. Basal cell carcinoma arising in a sternotomy scar: a report of three cases.  J Am Acad Dermatol. 1998;38((3)):491-493
PubMed   |  Link to Article
Bhargava R, Beriwal S, Dabbs DJ. Mammaglobin vs GCDFP-15: an immunohistologic validation survey for sensitivity and specificity.  Am J Clin Pathol. 2007;127((1)):103-113
PubMed   |  Link to Article
Freund H, Biran S, Laufer N, Eyal Z. Breast cancer arising in surgical scars.  J Surg Oncol. 1976;8((6)):477-480
PubMed   |  Link to Article
Freund H, Biran S, Laufer N, Eyal Z. Letter: breast cancer arising in thoracotomy scars.  Lancet. 1976;1((7950)):97
PubMed   |  Link to Article
Kim MJ, Kim EK, Lee JY,  et al.  Breast cancer from the excisional scar of a benign mass.  Korean J Radiol. 2007;8((3)):254-257
PubMed   |  Link to Article

Figures

Place holder to copy figure label and caption
Graphic Jump Location

Figure 2. Hematoxylin-eosin and immunohistochemisty-positive stainings. A, Hematoxylin-eosin staining of a biopsy showing pleomorphic cells in clusters and cords infiltrating the stroma, suggesting the possibility of a moderately differentiated carcinoma. B, Immunohistochemistry-positive staining for CK7. C, Immunohistochemistry-positive staining for CK20. D, Immunohistochemistry-positive staining for gross cystic disease fluid protein. Original magnification ×100 (A-D).

Tables

References

Gatto A, Sebastiani S, Falvo L, Giustiniani C, La Rovere C. A rare case of aggressive squamous-cell carcinoma of the breast skin: Marjolin's ulcer: a case report.  Chir Ital. 2008;60((4)):577-582
PubMed
Lau YS, Banwell PE, Pay AD. Basal cell carcinoma arising in scars: late presentation 16 years after a midline sternotomy.  Plast Reconstr Surg. 2004;113((4)):1297-1299
PubMed
Korula R, Hughes CF. Squamous cell carcinoma arising in a sternotomy scar.  Ann Thorac Surg. 1991;51((4)):667-669
PubMed   |  Link to Article
Dolan OM, Lowe L, Orringer MB, Rinek M, Johnson TM. Basal cell carcinoma arising in a sternotomy scar: a report of three cases.  J Am Acad Dermatol. 1998;38((3)):491-493
PubMed   |  Link to Article
Bhargava R, Beriwal S, Dabbs DJ. Mammaglobin vs GCDFP-15: an immunohistologic validation survey for sensitivity and specificity.  Am J Clin Pathol. 2007;127((1)):103-113
PubMed   |  Link to Article
Freund H, Biran S, Laufer N, Eyal Z. Breast cancer arising in surgical scars.  J Surg Oncol. 1976;8((6)):477-480
PubMed   |  Link to Article
Freund H, Biran S, Laufer N, Eyal Z. Letter: breast cancer arising in thoracotomy scars.  Lancet. 1976;1((7950)):97
PubMed   |  Link to Article
Kim MJ, Kim EK, Lee JY,  et al.  Breast cancer from the excisional scar of a benign mass.  Korean J Radiol. 2007;8((3)):254-257
PubMed   |  Link to Article

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