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Original Article |

Cancer Surgery in Low-Income Countries:  An Unmet Need

David E. Gyorki, MD; Arturo Muyco, MD; Adam L. Kushner, MD; Murray F. Brennan, MD; T. Peter Kingham, MD
Arch Surg. 2012;147(12):1135-1140. doi:10.1001/archsurg.2012.1265.
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Objectives  To describe the surgical oncology experience at a major regional hospital in Malawi and to identify barriers to improved outcomes.

Design  Retrospective review of operating logbooks from a single tertiary referral center.

Setting  Major tertiary referral center (Kamuzu Central Hospital) in Lilongwe, Malawi, in sub-Saharan Africa.

Patients  Patients were identified with a suspected diagnosis of cancer from January 1, 2004, through March 7, 2007.

Main Outcome Measures  Cancer cases were classified according to patient demographic characteristics, disease location, and therapeutic intent. The Malawi data were compared with US data from the Surveillance Epidemiology and End Results database.

Results  A malignant diagnosis was suspected in 255 of the 1440 patients undergoing a major resection (17.8%) (mean patient age, 53 years). The most common cancers in males were prostate, esophageal, and gastric. In females, the most common cancers were breast, colon, and esophageal. Many of the procedures were performed with palliative intent.

Conclusions  Cancer surgery comprises a significant proportion of the surgical caseload in low-income countries. Patients often present with late-stage, inoperable cancer. The participation of the surgical community is critical for addressing barriers to effective cancer care.

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Figures

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Figure 1. Ratios of cancer mortality to incidence stratified by a country's wealth demonstrate the clear disparity in outcomes related to income (calculated from International Agency for Research on Cancer data).3 Reprinted from Farmer P, Frenk J, Knaul FM, et al. Expansion of cancer care and control in countries of low and middle income: a call to action. Lancet. 2010;376(9747):1186-1193. With permission from Elsevier.

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Figure 2. Number of cases by patient sex seen at Kamuzu Central Hospital.

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Figure 3. Proportion of patients treated at Kamuzu Central Hospital compared with proportional incidence from the Surveillance Epidemiology and End Results (SEER) database (2006) for each cancer type by age.

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Figure 4. Comparison of proportion of cancer types seen in Malawi with that reported by the International Agency for Research on Cancer (GLOBOCAN) for less developed countries in 2008. Upper gastrointestinal (GI) cancer refers to both esophageal and gastric cancers. Cervical cancer cases were not included in the Malawi analysis. Skin cancer and head and neck cancer were not included in the GLOBOCAN data.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

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