Accepted for Publication: October 5, 2012.
Published Online: January 16, 2013. doi:10.1001/jamasurg.2013.1372
Author Contributions: Drs Oxman and Issa contributed equally to this work. Dr Issa had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Oxman, Marty, Panizales, McKenna, Frendl, Bueno, Sugarbaker, and Baden. Acquisition of data: Oxman, Issa, Patel, Panizales, Johnson, Licona, Frendl, Mentzer, Jaklitsch, Swanson, Sugarbaker, and Baden. Analysis and interpretation of data: Oxman, Issa, Marty, Panizales, Licona, Frendl, Colson, and Baden. Drafting of the manuscript: Oxman, Issa, Panizales, Frendl, Sugarbaker, and Baden. Critical revision of the manuscript for important intellectual content: Oxman, Issa, Marty, Patel, Johnson, Licona, McKenna, Frendl, Mentzer, Jaklitsch, Bueno, Colson, Swanson, Sugarbaker, and Baden. Statistical analysis: Issa, Marty, and Panizales. Obtained funding: Frendl and Baden. Administrative, technical, and material support: Marty, Patel, Panizales, Johnson, Licona, McKenna, Frendl, Bueno, Sugarbaker, and Baden. Study supervision: Oxman, Issa, Marty, Frendl, and Baden.
Conflicts of Interest Disclosures: None reported.
Funding/Support: Funding for the study was provided by the Division of Infectious Diseases and the Surgical Intensive Care Unit Translational Research Center, Brigham and Women's Hospital, Boston, Massachusetts.
Role of the Sponsors: The Division of Infectious Diseases and the Surgical Intensive Care Unit Translational Research Center did not participate in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Additional Contributions: We thank Belisa B. Guzman-Suarez, MD, and Kimberly Cheng, BA, for their assistance in the data collection and analysis and the Brigham and Women's Hospital Investigational Drug Service team.