A 50-year-old previously healthy man presented to the emergency department with epigastric pain for the past 3 months. He reported a 13.6-kg weight loss during this period with no nausea, vomiting, or diarrhea. He reported pruritus and dark, brown urine. He was notably jaundiced on physical examination, and his total bilirubin level was 7.7 mg/dL (to convert to micromoles per liter, multiply by 17.104). Notable laboratory findings include a Westergren erythrocyte sedimentation rate greater than 100 mm/h and a total protein level of 9.0 g/dL (reference range, 6.1-7.7 g/dL; to convert to grams per liter, multiply by 10.0). His medical history was significant for a cholecystectomy, nephrolithiasis, hypertension, and hypercholesterolemia.