The half-life of parathyroid hormone (PTH) may be affected by patient characteristics, including age, sex, race, body mass, index (BMI), and renal function. In this study by Leiker et al of 306 patients who underwent minimally invasive parathyroidectomy with intraoperative PTH (IOPTH) monitoring, IOPTH kinetic profiles were fitted to an exponential decay curve to determine the half-life of the IOPTH for individual patients. The median IOPTH half-life was 3 minutes, 9 seconds. On multivariate median regression analysis, age, BMI, and age × BMI interaction affected the IOPTH half-life. The IOPTH half-life increased with increasing BMI, although this effect was negligible after age 55 years. However, the differences are relatively small, and the clinical implications are likely not significant. Current IOPTH criteria can continue to be applied to all patients undergoing parathyroidectomy for sporadic primary hyperparathyroidism.