Effect of Diphenhydramine on Glycine-Produced Hyperammonemia in Dogs

Joseph C. Darin, MD; Joseph E. Rood Jr; J. David Lewis, MD; Alfredo Y. Ycasas, MD
Arch Surg. 1972;104(1):81-82. doi:10.1001/archsurg.1972.04180010075019.
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Hyperammonemia produced by an infusion of glycine in dogs leads to death within four hours. Concurrent treatment with a total dose of 15 or 20 mg/kg of diphenhydramine hydrochloride (Benadryl) significantly reduces the mortality to 12%. Although the surviving animals have lower average peak ammonia levels, there is no dose-specific relationship between the dose of diphenhydramine and the level of hyperammonemia. The mechanism of action of diphenhydramine remains unanswered.


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