JAMA Surgery Clinical Challenge |

Rare Complication After Viral Illness

Bassan J. Allan, MD1,2; Angela T. Prescott, MD1,2; Joseph A. Greene, MD1,2; German Campuzano-Zuluaga, MD1,2; Antonio Marttos, MD1,2
[+] Author Affiliations
1Division of Trauma and Acute Care Surgery, Department of Surgery, University of Miami, Miami, Florida
2Department of Pathology, University of Miami, Miami, Florida
JAMA Surg. 2013;148(10):983-984. doi:10.1001/jamasurg.2013.313.
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Figure 1.

Ultrasonography image of the right (A) and left (B) upper quadrants of the abdomen.

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Figure 2.

Results of pathological review of the spleen specimen. A, The resected spleen specimen with a large area of disruption of the splenic capsule measuring 16 cm × 15 cm × 14 cm and weighing 574 g. B, Immunoperoxidase staining for CD20 reveals immunoblastic proliferation of B cells with apoptotic debris and few normal follicles in the presence of global architectural disruption (original magnification ×10). C, Epstein-Barr virus in situ hybridization with RNA probe confirms infectious etiology of the splenic rupture (original magnification ×10).

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