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Original Investigation | Association of VA Surgeons

Consequences of Radial Artery Harvest:  Results of a Prospective, Randomized, Multicenter Trial FREE

William L. Holman, MD1; James E. Davies, MD1; Julia Y. Lin, PhD2; Yajie Wang, PhD2; Steven Goldman, MD3; Faisal G. Bakaeen, MD4; Rosemary Kelly, MD5; Stephen E. Fremes, MD6; Kelvin K. Lee, PhD2; Todd H. Wagner, PhD2; Gulshan K. Sethi, MD3 ; for the VA CSP 474 Investigators
[+] Author Affiliations
1Department of Surgery, Birmingham, Alabama VA Medical Center, Birmingham
2CSP Coordinating Center, VA Palo Alto Health Care System, Mountain View, California
3Department of Medicine and Surgery, Southern Arizona VA Health Care System, Tucson
4Department of Surgery, Michael E. DeBakey VA Medical Center, Houston, Texas
5Department of Surgery, Minneapolis VA Medical Center, Minneapolis, Minnesota
6Department of Surgery, Sunnybrook Health Sciences Center, Toronto, Ontario, Canada
JAMA Surg. 2013;148(11):1020-1023. doi:10.1001/jamasurg.2013.3721.
Text Size: A A A
Published online

Importance  To date, no study has defined the consequences of radial artery harvest based on a large number of patients in a prospective randomized trial.

Objective  To compare pain at the harvest site and functional changes associated with harvesting the radial artery vs saphenous vein for coronary artery bypass grafting.

Design, Setting, and Participants  This study compares the consequences of radial artery harvest with saphenous vein harvest in patients undergoing elective coronary artery bypass grafting procedures in Veterans Affairs hospitals.

Main Outcomes and Measures  Eleven hospitals screened 6148 patients, of whom 751 were included in this trial. We analyzed 2 variables: pain at the harvest site as measured on a scale of 0 to 100 (least to most painful) and hand performance testing. Patients included in this analysis had radial artery only (n = 80) or saphenous vein only (n = 337) harvest. Pain score, grip strength, and dexterity were measured before surgery and at 3 and 12 months after surgery. We adjusted for pain scores of the nonharvested extremity, age, whether the patient underwent endoscopic vein harvesting, and comorbid health conditions (smoking history, type 2 diabetes mellitus, hypertension, and heart failure).

Results  There was a significant difference in change of pain score at 3 months from the preoperative baseline between radial artery and saphenous vein groups after adjusting for covariates (P < .001) but not at 12 months (P = .07). No significant changes occurred in grip strength or dexterity from preoperative baseline to 3 and 12 months after surgery (P > .05).

Conclusions and Relevance  The radial artery group reported significantly more pain than the saphenous vein group 3 months after surgery; however, similar levels of pain were observed in both groups at 12 months after surgery. Grip strength and manual dexterity were not changed by radial artery harvesting at 3 and 12 months.

Figures in this Article

The Department of Veterans Affairs (VA) Cooperative Studies Program (CSP) 474 is a multicenter prospective randomized trial with a primary end point of angiographic graft patency at 1 year following coronary artery bypass grafting.1 The CSP 474 trial compares the radial artery with the saphenous vein, with the study conduit used as the graft to the best epicardial target vessel after the left anterior descending artery. Data acquisition included measurements of hand and forearm neuromuscular function, as well as leg pain, before and after surgery.

This report is a post hoc analysis of prospectively gathered data describing arm and leg neurologic outcome for the patients enrolled in CSP 474. The purpose is to quantitatively define the severity of pain and motor impairment associated with procurement of the radial artery and then compare pain and motor impairment with the unoperated-on arm. Postoperative data were obtained to measure recovery toward the preoperative baseline. Also, data describing pain in the lower extremities were collected to compare radial artery and saphenous vein procurement.

Based on a review of previously published information,215 the hypothesis tested in this study is that sensory and motor dysfunction associated with procurement of the radial artery largely resolves within a year of surgery and is not substantially worse than the discomfort associated with procurement of the saphenous vein. To our knowledge, no trial to date includes all attributes of CSP 474 (ie, a multicenter prospective randomized trial with quantitative assessments of pain and motor function by trained personnel that use widely accepted measurement tools at specified times before and after surgery) (details of prior literature in Table 1).

Table Graphic Jump LocationTable 1.  Summary of Neurologic Function After Radial Artery Harvest

The CSP 474 trial was approved by each site’s institutional review board, and written consent was obtained from each patient before screening. Patients undergoing primary sternotomy for coronary artery bypass grafting with no concomitant valve surgery were included. Other details of the study are available in a previous publication.1

Demographic data and data describing the patients’ cardiac disease were obtained. Intraoperative variables included the quality of the conduits used for grafts, the site of harvesting for all conduits, and a description of the proximal and distal anastomotic sites.

With regard to arm and leg function, data were collected before surgery (preoperative baseline) and 3 and 12 months following surgery. The case report forms for hand and leg pain, hand strength, and hand sensory function are included in the eFigure in the Supplement. Questions with a 0 (no pain) to 10 (most intense pain imaginable) scale that describes pain at rest and during activity were included. Right and left hand strengths were measured in pounds of grip using a commercially available dynamometer.16 Three attempts were averaged for the final value. Right and left manual dexterity was measured in seconds using the 9-hole peg test.17

Patients were stratified according to the operative sites so that the following comparisons could be made: arm pain, sensation, strength, and dexterity before and after radial artery harvest; arm pain, sensation, strength, and dexterity comparing the side of radial artery harvest with the unoperated-on side; saphenous vein harvest site pain before and after vein harvest; and saphenous vein harvest site pain compared with the unoperated-on leg. Additional descriptors for hand and forearm neurologic dysfunction obtained at each time point are listed on Form 10 in the eFigure in the Supplement.

Data were gathered and then reviewed for spurious values. Study coordinators attended a national meeting every year to review data collection methods and discuss problems. All patients provided informed consent before inclusion in the study, and each site obtained approval from its local institutional review board before participation. Data analysis occurred at a core VA facility affiliated with the Palo Alto VA Medical Center. Statistical comparisons assessed for significant changes in pain score from the preoperative baseline to 3 and 12 months postoperatively using mixed regression models to account for within-patient correlation of the outcomes. The analysis adjusted for pain scores of the nonharvested extremity, age, whether the patient underwent endoscopic vein harvesting, and comorbid health conditions (smoking history, type 2 diabetes mellitus, hypertension, and heart failure). A similar analysis was performed to assess grip strength and dexterity for patients undergoing radial artery harvest.

Forearm or hand pain and pain at the saphenous vein harvest site are shown in Table 2 and Figure 1.

Table Graphic Jump LocationTable 2.  Comparisons for Radial Artery and Saphenous Vein Harvest
Place holder to copy figure label and caption
Figure 1.
Radial Artery (RA) vs Saphenous Vein (SV) Comparisons: Pain Score by Group

Pain scores are depicted for the saphenous vein and radial artery harvest groups. The pain score is based on a Likert scale. Pain was measured before surgery (time 0) and at 3 and 12 months after surgery.

Graphic Jump Location

There was an increase in pain at 3 months after radial artery harvest; however, the pain resolved during 12 months. Pain noted in the control (non–radial artery harvest) arm may be related to placement of a radial artery catheter for pressure monitoring, positioning during surgery, or the placement of intravenous catheters for infusion. This discomfort also resolved over time.

Pain after surgery in the leg used for vein harvesting was less intense at 3 months after surgery compared with the radial harvest site; however, the pattern of pain diminution during the first year after surgery was similar to that of the upper extremity following radial artery harvesting (Figure 1).

Changes in grip strength and manual dexterity at 3 months and 1 year after surgery are described in Table 2 and illustrated in Figure 2 and Figure 3. A statistically insignificant decrease in grip strength after surgery remained stable at 1 year. There was an insignificant change in the 9-hole peg test performance after radial artery harvest.

Place holder to copy figure label and caption
Figure 2.
Radial Artery vs Saphenous Vein Comparisons: Grip Strength in Radial Artery Harvest Arm

Hand strength (in pounds) for the hand ipsilateral to the radial artery harvest site. Measurements were made before surgery (time 0) and at 3 and 12 months after surgery.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 3.
Radial Artery vs Saphenous Vein Comparisons: 9-Hole Peg Test in Radial Artery Harvest Arm

Time (in seconds) required to complete a standardized 9-hole peg test using the arm ipsilateral to the radial artery harvest site. The 9-hole peg test was performed before surgery (time 0) and at 3 and 12 months after surgery.

Graphic Jump Location

In the CSP 474 multicenter trial, a primary end point was conduit patency (ie, radial artery vs saphenous vein) at 1 year after coronary artery bypass grafting. When the executive committee developed the trial’s design, it recognized the importance of measuring pain and assessing neurologic function of the operated-on extremity and then comparing arms and legs after conduit procurement. The final study design had structured examinations for pain (arm and leg) and neurologic function (sensory and motor examinations; arm only) by specially trained personnel. Pain assessment was measured using scripted questions with Likert-type scales. Scripted questions were used together with devices for rating manual dexterity (9-hole peg test) and grip strength (dynanometer).16,17

The statistical analysis included a consideration of risk factors for pain and motor dysfunction. The study group was confined to patients with only radial artery or saphenous vein harvest so that simultaneous postincision arm and leg pain never confounded the arm and leg comparison.

The consequences of radial artery harvest with regard to pain and hand function are important. Prior investigations examined this issue as part of studies of patient survival or graft patency or as a separate entity. To our knowledge, this study is the only one that has used a prospective randomized multicenter trial design that included scripted questions and examinations by specially trained personnel. This study provides the most secure and detailed information yet to address an important question for patients considering coronary artery bypass grafting with the use of a radial artery.

In summary, analysis of data collected as part of CSP 474 found that pain after radial artery procurement was slightly greater than pain after saphenous vein harvest. However, the pain was not severe and resolved within 12 months following surgery. There was no statistically significant change in manual dexterity or grip strength at 3 or 12 months after surgery compared with the preoperative status. The 9-hole peg test and grip strength cannot discern changes in sensory or motor function for especially demanding situations (eg, the hands of a pianist) but are nevertheless reassuring regarding the outcome for most patients who undergo this procedure.

Accepted for Publication: May 23, 2013.

Corresponding Author: William L. Holman, MD, Department of Surgery, Birmingham, Alabama VA Medical Center, 700 S 19th St, Birmingham, AL 35233 (wholman@uab.edu).

Published Online: September 25, 2013. doi:10.1001/jamasurg.2013.3721.

Author Contributions: Drs Holman and Goldman had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Study concept and design: Holman, Goldman, Kelly, Fremes, Lee, Sethi.

Acquisition of data: Holman, Wang, Goldman, Lee, Wagner, Sethi.

Analysis and interpretation of data: All authors.

Drafting of the manuscript: Holman, Davies, Lin, Sethi.

Critical revision of the manuscript for important intellectual content: Holman, Davies, Wang, Goldman, Bakaeen, Kelly, Fremes, Lee, Wagner, Sethi.

Statistical analysis: Holman, Lin, Wang, Bakaeen, Lee, Wagner, Sethi.

Obtained funding: Goldman, Wagner, Sethi.

Administrative, technical, and material support: Holman, Davies, Kelly, Lee, Wagner, Sethi.

Study supervision: Holman, Goldman, Fremes, Sethi.

Conflict of Interest Disclosures: None reported.

Group Information: The VA CSP 474 Investigators are listed at http://jama.jamanetwork.com/article.aspx?articleid=892716.

Previous Presentation: This study was presented at the 2013 Association of VA Surgeons Annual Meeting; April 22, 2013; Milwaukee, Wisconsin.

Goldman  S, Sethi  GK, Holman  W,  et al.  Radial artery grafts vs saphenous vein grafts in coronary artery bypass surgery: a randomized trial. JAMA. 2011;305(2):167-174.
PubMed   |  Link to Article
Grossebner  M, Arifi  A, Bourov  Y, Taylor  G, Gray  S, Ritchie  A.  No change in O2 saturation but measurable difference in thenar flexor power after radial artery harvest. Eur J Cardiothorac Surg. 1999;16(2):160-162.
PubMed   |  Link to Article
Saeed  I, Anyanwu  AC, Yacoub  MH, Amrani  M.  Subjective patient outcomes following coronary artery bypass using the radial artery: results of a cross-sectional survey of harvest site complications and quality of life. Eur J Cardiothorac Surg. 2001;20(6):1142-1146.
PubMed   |  Link to Article
Meharwal  ZS, Trehan  N.  Functional status of the hand after radial artery harvesting. Ann Thorac Surg. 2001;72(5):1557-1561.
PubMed   |  Link to Article
Denton  TA, Trento  L, Cohen  M,  et al.  Radial artery harvesting for coronary bypass operations. J Thorac Cardiovasc Surg. 2001;121(5):951-956.
PubMed   |  Link to Article
Budillon  AM, Nicolini  F, Agostinelli  A,  et al.  Complications after radial artery harvesting for coronary artery bypass grafting. Surgery. 2003;133(3):283-287.
PubMed   |  Link to Article
Siminelakis  S, Karfis  E, Anagnostopoulos  C, Toumpoulis  I, Katsaraki  A, Drossos  G.  Harvesting radial artery and neurologic complications. J Card Surg. 2004;19(6):505-510.
PubMed   |  Link to Article
Desai  ND, Cohen  EA, Naylor  CD, Fremes  SE; Radial Artery Patency Study Investigators.  A randomized comparison of radial-artery and saphenous-vein coronary bypass grafts. N Engl J Med. 2004;351(22):2302-2309.
PubMed   |  Link to Article
Shapira  OM, Eskenazi  BR, Hunter  CT,  et al.  Endoscopic versus conventional radial artery harvest—is smaller better? J Card Surg. 2006;21(4):329-335.
PubMed   |  Link to Article
Oz  BS, Mataraci  I, Iyem  H,  et al.  Comparison of ultrasonically activated scalpel and traditional technique in radial artery harvesting: clinical research. Thorac Cardiovasc Surg. 2007;55(2):104-107.
PubMed   |  Link to Article
Medalion  B, Fuks  A, Sharoni  E,  et al.  Limb performance and patient satisfaction after radial artery harvesting. Surg Endosc. 2008;22(12):2638-2642.
PubMed   |  Link to Article
Shah  SA, Chark  D, Williams  J,  et al.  Retrospective analysis of local sensorimotor deficits after radial artery harvesting for coronary artery bypass grafting. J Surg Res. 2007;139(2):203-208.
PubMed   |  Link to Article
Collins  P, Webb  CM, Chong  CF, Moat  NE; Radial Artery Versus Saphenous Vein Patency (RSVP) Trial Investigators.  Radial artery versus saphenous vein patency randomized trial: five-year angiographic follow-up. Circulation. 2008;117(22):2859-2864.
PubMed   |  Link to Article
Dick  F, Hristic  A, Roost-Krähenbühl  E,  et al.  Persistent sensitivity disorders at the radial artery and saphenous vein graft harvest sites. Eur J Cardiothorac Surg. 2011;40(1):221-226.
PubMed   |  Link to Article
Zhu  YY, Hayward  PAR, Hadinata  IE,  et al.  Long-term impact of radial artery harvest on forearm function and symptoms. J Thorac Cardiovasc Surg. 2013;145(2):412-419.
PubMed   |  Link to Article
Mathiowetz  V, Kashman  N, Volland  G, Weber  K, Dowe  M, Rogers  S.  Grip and pinch strength: normative data for adults. Arch Phys Med Rehabil. 1985;66(2):69-74.
PubMed
Yancosek  KE, Howell  D.  A narrative review of dexterity assessments. J Hand Ther. 2009;22(3):258-270.
PubMed   |  Link to Article

Figures

Place holder to copy figure label and caption
Figure 1.
Radial Artery (RA) vs Saphenous Vein (SV) Comparisons: Pain Score by Group

Pain scores are depicted for the saphenous vein and radial artery harvest groups. The pain score is based on a Likert scale. Pain was measured before surgery (time 0) and at 3 and 12 months after surgery.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.
Radial Artery vs Saphenous Vein Comparisons: Grip Strength in Radial Artery Harvest Arm

Hand strength (in pounds) for the hand ipsilateral to the radial artery harvest site. Measurements were made before surgery (time 0) and at 3 and 12 months after surgery.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 3.
Radial Artery vs Saphenous Vein Comparisons: 9-Hole Peg Test in Radial Artery Harvest Arm

Time (in seconds) required to complete a standardized 9-hole peg test using the arm ipsilateral to the radial artery harvest site. The 9-hole peg test was performed before surgery (time 0) and at 3 and 12 months after surgery.

Graphic Jump Location

Tables

Table Graphic Jump LocationTable 1.  Summary of Neurologic Function After Radial Artery Harvest
Table Graphic Jump LocationTable 2.  Comparisons for Radial Artery and Saphenous Vein Harvest

References

Goldman  S, Sethi  GK, Holman  W,  et al.  Radial artery grafts vs saphenous vein grafts in coronary artery bypass surgery: a randomized trial. JAMA. 2011;305(2):167-174.
PubMed   |  Link to Article
Grossebner  M, Arifi  A, Bourov  Y, Taylor  G, Gray  S, Ritchie  A.  No change in O2 saturation but measurable difference in thenar flexor power after radial artery harvest. Eur J Cardiothorac Surg. 1999;16(2):160-162.
PubMed   |  Link to Article
Saeed  I, Anyanwu  AC, Yacoub  MH, Amrani  M.  Subjective patient outcomes following coronary artery bypass using the radial artery: results of a cross-sectional survey of harvest site complications and quality of life. Eur J Cardiothorac Surg. 2001;20(6):1142-1146.
PubMed   |  Link to Article
Meharwal  ZS, Trehan  N.  Functional status of the hand after radial artery harvesting. Ann Thorac Surg. 2001;72(5):1557-1561.
PubMed   |  Link to Article
Denton  TA, Trento  L, Cohen  M,  et al.  Radial artery harvesting for coronary bypass operations. J Thorac Cardiovasc Surg. 2001;121(5):951-956.
PubMed   |  Link to Article
Budillon  AM, Nicolini  F, Agostinelli  A,  et al.  Complications after radial artery harvesting for coronary artery bypass grafting. Surgery. 2003;133(3):283-287.
PubMed   |  Link to Article
Siminelakis  S, Karfis  E, Anagnostopoulos  C, Toumpoulis  I, Katsaraki  A, Drossos  G.  Harvesting radial artery and neurologic complications. J Card Surg. 2004;19(6):505-510.
PubMed   |  Link to Article
Desai  ND, Cohen  EA, Naylor  CD, Fremes  SE; Radial Artery Patency Study Investigators.  A randomized comparison of radial-artery and saphenous-vein coronary bypass grafts. N Engl J Med. 2004;351(22):2302-2309.
PubMed   |  Link to Article
Shapira  OM, Eskenazi  BR, Hunter  CT,  et al.  Endoscopic versus conventional radial artery harvest—is smaller better? J Card Surg. 2006;21(4):329-335.
PubMed   |  Link to Article
Oz  BS, Mataraci  I, Iyem  H,  et al.  Comparison of ultrasonically activated scalpel and traditional technique in radial artery harvesting: clinical research. Thorac Cardiovasc Surg. 2007;55(2):104-107.
PubMed   |  Link to Article
Medalion  B, Fuks  A, Sharoni  E,  et al.  Limb performance and patient satisfaction after radial artery harvesting. Surg Endosc. 2008;22(12):2638-2642.
PubMed   |  Link to Article
Shah  SA, Chark  D, Williams  J,  et al.  Retrospective analysis of local sensorimotor deficits after radial artery harvesting for coronary artery bypass grafting. J Surg Res. 2007;139(2):203-208.
PubMed   |  Link to Article
Collins  P, Webb  CM, Chong  CF, Moat  NE; Radial Artery Versus Saphenous Vein Patency (RSVP) Trial Investigators.  Radial artery versus saphenous vein patency randomized trial: five-year angiographic follow-up. Circulation. 2008;117(22):2859-2864.
PubMed   |  Link to Article
Dick  F, Hristic  A, Roost-Krähenbühl  E,  et al.  Persistent sensitivity disorders at the radial artery and saphenous vein graft harvest sites. Eur J Cardiothorac Surg. 2011;40(1):221-226.
PubMed   |  Link to Article
Zhu  YY, Hayward  PAR, Hadinata  IE,  et al.  Long-term impact of radial artery harvest on forearm function and symptoms. J Thorac Cardiovasc Surg. 2013;145(2):412-419.
PubMed   |  Link to Article
Mathiowetz  V, Kashman  N, Volland  G, Weber  K, Dowe  M, Rogers  S.  Grip and pinch strength: normative data for adults. Arch Phys Med Rehabil. 1985;66(2):69-74.
PubMed
Yancosek  KE, Howell  D.  A narrative review of dexterity assessments. J Hand Ther. 2009;22(3):258-270.
PubMed   |  Link to Article

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eFigure. Case Report Forms for Hand and Arm Pain, Hand Strength, and Hand Sensory Function

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