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Brief Report | Resident's Forum

Effect of Abdominal Insufflation for Laparoscopy on Intracranial Pressure FREE

Tovy Haber Kamine, MD1; Efstathios Papavassiliou, MD2; Benjamin E. Schneider, MD1
[+] Author Affiliations
1Department of Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts
2Department of Neurosurgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts
JAMA Surg. 2014;149(4):380-382. doi:10.1001/jamasurg.2013.3024.
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Importance  Increased abdominal pressure may have a negative effect on intracranial pressure (ICP). Human data on the effects of laparoscopy on ICP are lacking. We retrospectively reviewed laparoscopic operations for ventriculoperitoneal shunt placement to determine the effect of insufflation on ICP.

Observations  Nine patients underwent insufflation with carbon dioxide (CO2) at pressures ranging from 8 to 15 mm Hg and ICP measured through a ventricular catheter. We used a paired t test to compare ICP with insufflation and desufflation. Linear regression correlated insufflation pressure with ICP. The mean ICP increase with 15–mm Hg insufflation is 7.2 (95% CI, 5.4-9.1 [P < .001]) cm H2O. The increase in ICP correlated with increasing insufflation pressure (P = .04). Maximum ICP recorded was 25 cm H2O.

Conclusions and Relevance  Intracranial pressure significantly increases with abdominal insufflation and correlates with laparoscopic insufflation pressure. The maximum ICP measured was a potentially dangerous 25 cm H2O. Laparoscopy should be used cautiously in patients with a baseline elevated ICP or head trauma.

Figures in this Article

Diagnostic and therapeutic laparoscopy has emerged as an alternative to trauma laparotomy. Laparoscopy is used to control hemorrhage and repair the diaphragm, stomach, bowel, and bladder during colectomy, pancreatectomy, and splenectomy in blunt and penetrating trauma.15 Therapeutically, laparoscopy is less morbid than laparotomy, and diagnostically it can obviate the need for a laparotomy.15

Unfortunately, abdominal and head trauma can coexist, and increasing intra-abdominal pressure increases intracranial pressure (ICP).68 Results of animal studies have shown that laparoscopy increases ICP.912 Various mechanisms have been proposed, including compression of the lumbar venous plexus, hypercarbia causing cerebral vasodilation due to carbon dioxide (CO2) insufflation, and inferior vena cava compression inhibiting cerebral venous drainage.10,11 Abdominal decompression may relieve elevated ICP.13,14 These data belie the lack of human data on the effects of laparoscopy on ICP.

The laparoscopy-assisted ventriculoperitoneal shunt (VPS) placement is ideal for examining the effects of abdominal insufflation for laparoscopy on ICP. At Beth Israel Deaconess Medical Center, ICP has been measured during this operation. We conducted a retrospective review of sequential laparoscopic VPS placement to examine the effect of laparoscopy on ICP.

Data Collection

Approval of the Beth Israel Deaconess Medical Center institutional review board was obtained. Retrospective medical record review was performed for sequential patients who underwent laparoscopy-assisted VPS placement from January 1, 2008, through December 31, 2011. Nine patients had ICP recorded on operative reports by the preference of the general surgeon or the neurosurgeon. Three neurosurgeons (including E.P.) and 4 general surgeons (including B.E.S.) were involved in the operations. Sixteen measurements were recorded with abdominal insufflation with CO2 at pressures ranging from 8 to 15 mm Hg. Intracranial pressure was measured through the ventricular catheter using a manometer with insufflation and desufflation. Baseline data obtained included age, sex, the presence of hypertension, the presence of cancer, weight, and prior abdominal or cranial surgery.

Statistical Analysis

When ICP was recorded as a range, we used the mean value in analysis. We performed a paired t test on ICP measurements between insufflation and desufflation. Linear regression and the correlation coefficient were calculated to correlate intraperitoneal pressure with ICP.

Fifty-five patients underwent laparoscopic VPS placement during the study period; in 9, ICP and intraperitoneal pressures were included in the operative report. Sixteen ICP measurements were obtained on these patients with intraperitoneal pressures ranging from 8 to 15 mm Hg. All patients had ICPs recorded with 15–mm Hg insufflation; 3, with 10– and 12–mm Hg insufflation; and 1, with 8–mm Hg insufflation. All patients received propofol and an inhaled anesthetic agent (sevoflurane or desflurane). The mean age was 65.1 (range, 34-82) years. Indications for VPS placement included normal-pressure hydrocephalus (5 patients), traumatic subdural hematoma (2 patients), meningioma (1 patient), and metastatic melanoma (1 patient). Four patients were men and 5 were women. No baseline data significantly affected ICP change.

Intracranial pressure ranged from 0 to 18 cm H2O with desufflation and from 8 to 25 cm H2O with 15–mm Hg CO2 insufflation. The highest recorded ICP was 25 cm H2O. Mean ICP increase correlated significantly with insufflation pressure. The mean increase in ICP was 7.2 (95% CI, 5.4-9.1) cm H2O with 15–mm Hg insufflation (P < .001), 6.3 (0.6-12.1) cm H2O with 12–mm Hg insufflation (P = .04), and 4.8 (1.0-8.6) cm H2O with 10–mm Hg insufflation (P = .03). Increasing insufflation pressure correlated with increased ICP (P = .04) (Figure).

Place holder to copy figure label and caption
Figure.
Effect of Insufflation Pressure on the Increase in Intracranial Pressure (ICP)

Intracranial pressure is measured against the desufflation baseline. Increasing insufflation pressure correlated with increased ICP (P = .04). Line indicates correlation; circles, individual patients.

Graphic Jump Location

Elevated ICP is associated with cerebral ischemia and is predictive of deterioration after head trauma; decreasing ICP to less than 20 cm H2O and keeping cerebral perfusion pressure (CPP) at greater than 50 mm Hg is the priority in patients with head injury according to the Brain Trauma Foundation.15 The maximum ICP measured in our study was a potentially dangerous 25 cm H2O. In patients with head injuries after trauma, an elevated ICP for the duration of a therapeutic or even a diagnostic laparoscopy could cause irreparable brain damage.

In our study, the ICP increase correlated linearly with the abdominal insufflation pressure. This finding is consistent with the previous animal data and suggests that this increase may be due to the effect of increased abdominal pressure on central venous pressure, as suggested by Rosenthal et al.9 Although a wide range of ICPs were noted during insufflation and desufflation—likely owing in part to the primary brain disease necessitating placement of the VPS—a strong correlation was shown between insufflation pressure and ICP. Unfortunately, we had only a small number of patients and were unable to evaluate the response in different brain diseases. Because of the limitations of the laparoscopic VPS procedure and anesthesia record, we were unable to measure ICP at the onset and close of the procedure or to correlate end-tidal CO2 levels with insufflation and thus could not determine the effect of longer CO2 insufflation and potential subsequent hypercarbia on ICP, as suggested by Schöb et al.11 This potential for CO2 absorption might make laparoscopy even more dangerous in patients with already elevated ICP because ICP may continue to rise throughout the operation. Furthermore, laparoscopic operations may aggravate the multiple compartment syndrome—a combination of elevated intra-abdominal and intrathoracic pressures and ICP16—owing to the combination of abdominal insufflation and positive pressure ventilation. The linear relationship in our study between ICP and insufflation pressure suggests that any increase in abdominal pressure can be harmful in the patient with head injury. If laparoscopy is to be performed, a lower-than-standard insufflation pressure may be safer, although future study is necessary to determine its safety and feasibility.

Because our study was retrospective and limited by the anesthesia record, we were unable to correlate blood pressures with insufflation and thus could not measure the CPP. However, if the CPP were greater than 60 mm Hg, CPP may have less bearing than ICP on the prognosis of patients with head injury.15 Further studies will need to determine the correlation between insufflation pressure and CPP in human patients. Another potential concern is the small size of our study. Despite the small number of patients, the impact of laparoscopy was still striking enough to afford a significant P value. However, a larger study might determine which factors place a patient at higher risk of a larger, potentially devastating rise in ICP with laparoscopy.

In patients undergoing laparoscopic VPS placement, ICP is significantly increased with abdominal insufflation for laparoscopy, and sequentially increased insufflation pressures significantly correlate with increased ICP. More research is needed to determine the effect of laparoscopy on CPP. These data suggest that laparoscopy should be used cautiously, if at all, in patients with a baseline elevated ICP or with head trauma.

Section Editor: Richard D. Schulick, MD, MBA; Pamela A. Lipsett, MD, MPHE.

Accepted for Publication: April 29, 2013.

Corresponding Author: Benjamin E. Schneider, MD, Department of Surgery, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Shapiro 3, Boston, MA 02215 (beschnei@bidmc.harvard.edu).

Published Online: February 12, 2014. doi:10.1001/jamasurg.2013.3024.

Author Contributions: Drs Kamine and Schneider had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Study concept and design: All authors.

Acquisition of data: All authors.

Analysis and interpretation of data: Kamine, Schneider.

Drafting of the manuscript: All authors.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Kamine.

Administrative, technical, or material support: Papavassiliou, Schneider.

Study supervision: Papavassiliou, Schneider.

Conflict of Interests Disclosures: None reported.

Previous Presentation: This paper was presented as a poster of distinction at Digestive Disease Week; May 21, 2012; San Diego, California.

Fabian  TC, Croce  MA, Stewart  RM, Pritchard  FE, Minard  G, Kudsk  KA.  A prospective analysis of diagnostic laparoscopy in trauma. Ann Surg. 1993;217(5):557-565.
PubMed   |  Link to Article
Gorecki  PJ, Cottam  D, Angus  LD, Shaftan  GW.  Diagnostic and therapeutic laparoscopy for trauma: a technique of safe and systematic exploration. Surg Laparosc Endosc Percutan Tech. 2002;12(3):195-198.
PubMed   |  Link to Article
Zantut  LF, Ivatury  RR, Smith  RS,  et al.  Diagnostic and therapeutic laparoscopy for penetrating abdominal trauma: a multicenter experience. J Trauma. 1997;42(5):825-831.
PubMed   |  Link to Article
Chol  YB, Lim  KS.  Therapeutic laparoscopy for abdominal trauma. Surg Endosc. 2003;17(3):421-427.
PubMed   |  Link to Article
Smith  RS, Fry  WR, Morabito  DJ, Koehler  RH, Organ  CH  Jr.  Therapeutic laparoscopy in trauma. Am J Surg. 1995;170(6):632-637.
PubMed   |  Link to Article
Bloomfield  GL, Ridings  PC, Blocher  CR, Marmarou  A, Sugerman  HJ.  Effects of increased intra-abdominal pressure upon intracranial and cerebral perfusion pressure before and after volume expansion. J Trauma. 1996;40(6):936-943.
PubMed   |  Link to Article
Citerio  G, Vascotto  E, Villa  F, Celotti  S, Pesenti  A.  Induced abdominal compartment syndrome increases intracranial pressure in neurotrauma patients: a prospective study. Crit Care Med. 2001;29(7):1466-1471.
PubMed   |  Link to Article
Deeren  DH, Dits  H, Malbrain  ML.  Correlation between intra-abdominal and intracranial pressure in nontraumatic brain injury. Intensive Care Med. 2005;31(11):1577-1581.
PubMed   |  Link to Article
Rosenthal  RJ, Hiatt  JR, Phillips  EH, Hewitt  W, Demetriou  AA, Grode  M.  Intracranial pressure: effects of pneumoperitoneum in a large-animal model. Surg Endosc. 1997;11(4):376-380.
PubMed   |  Link to Article
Rosenthal  RJ, Friedman  RL, Chidambaram  A,  et al.  Effects of hyperventilation and hypoventilation on PaCO2 and intracranial pressure during acute elevations of intraabdominal pressure with CO2 pneumoperitoneum: large animal observations. J Am Coll Surg. 1998;187(1):32-38.
PubMed   |  Link to Article
Schöb  OM, Allen  DC, Benzel  E,  et al.  A comparison of the pathophysiologic effects of carbon dioxide, nitrous oxide, and helium pneumoperitoneum on intracranial pressure. Am J Surg. 1996;172(3):248-253.
PubMed   |  Link to Article
Josephs  LG, Este-McDonald  JR, Birkett  DH, Hirsch  EF.  Diagnostic laparoscopy increases intracranial pressure. J Trauma. 1994;36(6):815-819.
PubMed   |  Link to Article
Nagpal  S, Halpern  CH, Sims  C,  et al.  Decompressive laparotomy to treat intractable cerebral hypoxia. J Trauma. 2009;67(5):E152-E155. doi:10.1097/TA.0b013e3180593657.
PubMed   |  Link to Article
Saggi  BH, Bloomfield  GL, Sugerman  HJ,  et al.  Treatment of intracranial hypertension using nonsurgical abdominal decompression. J Trauma. 1999;46(4):646-651.
PubMed   |  Link to Article
Brain Trauma Foundation; American Association of Neurological Surgeons; Congress of Neurological Surgeons.  Guidelines for the management of severe traumatic brain injury. J Neurotrauma. 2007;24(suppl 1):S1-S106.
PubMed   |  Link to Article
Scalea  TM, Bochicchio  GV, Habashi  N,  et al.  Increased intra-abdominal, intrathoracic, and intracranial pressure after severe brain injury: multiple compartment syndrome. J Trauma. 2007;62(3):647-656.
PubMed   |  Link to Article

Figures

Place holder to copy figure label and caption
Figure.
Effect of Insufflation Pressure on the Increase in Intracranial Pressure (ICP)

Intracranial pressure is measured against the desufflation baseline. Increasing insufflation pressure correlated with increased ICP (P = .04). Line indicates correlation; circles, individual patients.

Graphic Jump Location

Tables

References

Fabian  TC, Croce  MA, Stewart  RM, Pritchard  FE, Minard  G, Kudsk  KA.  A prospective analysis of diagnostic laparoscopy in trauma. Ann Surg. 1993;217(5):557-565.
PubMed   |  Link to Article
Gorecki  PJ, Cottam  D, Angus  LD, Shaftan  GW.  Diagnostic and therapeutic laparoscopy for trauma: a technique of safe and systematic exploration. Surg Laparosc Endosc Percutan Tech. 2002;12(3):195-198.
PubMed   |  Link to Article
Zantut  LF, Ivatury  RR, Smith  RS,  et al.  Diagnostic and therapeutic laparoscopy for penetrating abdominal trauma: a multicenter experience. J Trauma. 1997;42(5):825-831.
PubMed   |  Link to Article
Chol  YB, Lim  KS.  Therapeutic laparoscopy for abdominal trauma. Surg Endosc. 2003;17(3):421-427.
PubMed   |  Link to Article
Smith  RS, Fry  WR, Morabito  DJ, Koehler  RH, Organ  CH  Jr.  Therapeutic laparoscopy in trauma. Am J Surg. 1995;170(6):632-637.
PubMed   |  Link to Article
Bloomfield  GL, Ridings  PC, Blocher  CR, Marmarou  A, Sugerman  HJ.  Effects of increased intra-abdominal pressure upon intracranial and cerebral perfusion pressure before and after volume expansion. J Trauma. 1996;40(6):936-943.
PubMed   |  Link to Article
Citerio  G, Vascotto  E, Villa  F, Celotti  S, Pesenti  A.  Induced abdominal compartment syndrome increases intracranial pressure in neurotrauma patients: a prospective study. Crit Care Med. 2001;29(7):1466-1471.
PubMed   |  Link to Article
Deeren  DH, Dits  H, Malbrain  ML.  Correlation between intra-abdominal and intracranial pressure in nontraumatic brain injury. Intensive Care Med. 2005;31(11):1577-1581.
PubMed   |  Link to Article
Rosenthal  RJ, Hiatt  JR, Phillips  EH, Hewitt  W, Demetriou  AA, Grode  M.  Intracranial pressure: effects of pneumoperitoneum in a large-animal model. Surg Endosc. 1997;11(4):376-380.
PubMed   |  Link to Article
Rosenthal  RJ, Friedman  RL, Chidambaram  A,  et al.  Effects of hyperventilation and hypoventilation on PaCO2 and intracranial pressure during acute elevations of intraabdominal pressure with CO2 pneumoperitoneum: large animal observations. J Am Coll Surg. 1998;187(1):32-38.
PubMed   |  Link to Article
Schöb  OM, Allen  DC, Benzel  E,  et al.  A comparison of the pathophysiologic effects of carbon dioxide, nitrous oxide, and helium pneumoperitoneum on intracranial pressure. Am J Surg. 1996;172(3):248-253.
PubMed   |  Link to Article
Josephs  LG, Este-McDonald  JR, Birkett  DH, Hirsch  EF.  Diagnostic laparoscopy increases intracranial pressure. J Trauma. 1994;36(6):815-819.
PubMed   |  Link to Article
Nagpal  S, Halpern  CH, Sims  C,  et al.  Decompressive laparotomy to treat intractable cerebral hypoxia. J Trauma. 2009;67(5):E152-E155. doi:10.1097/TA.0b013e3180593657.
PubMed   |  Link to Article
Saggi  BH, Bloomfield  GL, Sugerman  HJ,  et al.  Treatment of intracranial hypertension using nonsurgical abdominal decompression. J Trauma. 1999;46(4):646-651.
PubMed   |  Link to Article
Brain Trauma Foundation; American Association of Neurological Surgeons; Congress of Neurological Surgeons.  Guidelines for the management of severe traumatic brain injury. J Neurotrauma. 2007;24(suppl 1):S1-S106.
PubMed   |  Link to Article
Scalea  TM, Bochicchio  GV, Habashi  N,  et al.  Increased intra-abdominal, intrathoracic, and intracranial pressure after severe brain injury: multiple compartment syndrome. J Trauma. 2007;62(3):647-656.
PubMed   |  Link to Article

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