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Original Investigation | SURGICAL CARE OF THE AGING POPULATION

The Effect of Age on Glasgow Coma Scale Score in Patients With Traumatic Brain Injury

Kristin Salottolo, MPH1,2; A. Stewart Levy, MD3; Denetta S. Slone, MD1,4; Charles W. Mains, MD2,4; David Bar-Or, MD1,2,4
[+] Author Affiliations
1Department of Trauma Research, Swedish Medical Center, Englewood, Colorado
2Department of Trauma Research, St Anthony Hospital, Lakewood, Colorado
3InterMountain Neurosurgery, St Anthony Hospital, Lakewood, Colorado
4Department of Biomedical Sciences, Rocky Vista University, Aurora, Colorado
JAMA Surg. 2014;149(7):727-734. doi:10.1001/jamasurg.2014.13.
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Importance  The Glasgow Coma Scale (GCS) is used frequently to define the extent of neurologic injury in patients with a traumatic brain injury (TBI). Whether age affects the predictive ability of the GCS for severity of TBI (determined by the Abbreviated Injury Scale [AIS] score) remains unknown.

Objective  To investigate the effect of age on the association between the GCS and anatomic TBI severity.

Design, Setting, and Participants  We examined all patients with a TBI, defined by diagnostic codes 850 to 854 from the International Classification of Diseases, Ninth Revision, Clinical Modification, who were admitted to 2 level I trauma centers from January 1, 2008, through December 31, 2012.

Exposures  We compared elderly (≥65 years) and younger (18-64 years) adults with TBI.

Main Outcomes and Measures  We examined differences by age in GCS category (defined by emergency department GCS as severe [3-8], moderate [9-12], or mild [13-15]) at each level of TBI severity (head AIS score, 1 [minor] to 5 [critical]). Cochran-Armitage χ2 trend tests and stepwise multivariate linear and logistic regression models were used.

Results  During the study period, 6710 patients had a TBI (aged <65 years, 73.17%). Significant differences in GCS category by age occurred at each AIS score (P ≤ .01 for all). In particular, among patients with an AIS score of 5, most of the elderly patients (56.33%) had a mild neurologic deficit (GCS score, 13-15), whereas most of the younger patients (63.28%) had a severe neurologic deficit (GCS score, 3-8). After adjustment, the younger adults had increased odds of presenting with a severe neurologic deficit (GCS score, 3-8) at each of the following AIS scores: 1, 4.2 (95% CI, 1.0-17.6; P = .05); 2, 2.0 (1.0-3.7; P = .04); 3, 2.0 (1.2-3.5; P = .01); 4, 4.6 (2.8-7.5; P < .001); and 5, 3.1 (2.1-4.6; P < .001). The interaction between age and GCS for anatomic TBI severity remained significant after adjustment (estimate, −0.11; P = .005).

Conclusions and Relevance  Age affects the relationship between the GCS score and anatomic TBI severity. Elderly TBI patients have better GCS scores than younger TBI patients with similar TBI severity. These findings have implications for TBI outcomes research and for protocols and research selection criteria that use the GCS.

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Figure 1.
Presence of Severe Neurologic Deficit

We used a Glasgow Coma Scale (GCS) score of 3 to 8 to measure neurologic deficit stratified by head Abbreviated Injury Scale (AIS) score and age.

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Figure 2.
Mortality by Age

We stratified mortality by head Abbreviated Injury Scale (AIS) score and Glasgow Coma Scale (GCS) strata.aP < .05, χ2 test.bP < .001, χ2 test.

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