0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Original Investigation | Pacific Coast Surgical Association

Comparison of Short-term Outcomes in Laparoscopic vs Open Hepatectomy ONLINE FIRST

Cara Franken, MD1; Briana Lau, MD1; Krishna Putchakayala, MD1; L. Andrew DiFronzo, MD1
[+] Author Affiliations
1Department of Surgery, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California
JAMA Surg. Published online July 30, 2014. doi:10.1001/jamasurg.2014.1023
Text Size: A A A
Published online

Importance  Despite the increasing role of laparoscopy in partial hepatic resection, its short-term benefit compared with traditional open surgery remains unclear.

Objective  To compare short-term (30-day) outcomes between laparoscopic (LH) and open (OH) partial hepatectomies.

Design, Setting, and Participants  Retrospective matched case-control study from April 1, 2004, to March 31, 2013, in a tertiary hepatobiliary referral center. Patients who underwent partial hepatic resection (OH or LH) for benign or malignant disease were matched first by extent of resection, then by pathological diagnosis, and finally by age and sex to the extent possible.

Exposure  Partial hepatectomy for liver disease.

Main Outcomes and Measures  Thirty-day morbidity and mortality rates.

Results  After the matching process, we included 104 patients (52 undergoing LH and 52 undergoing OH) in the study. Patients were evenly matched with respect to age, sex, extent of resection, and diagnosis. Cirrhosis was present in 17 patients (33%) in each group. We found no difference in positive margin status (1 patient [2%] for LH vs 2 patients [4%] for OH; P > .99). Although the estimated blood loss differed significantly between groups (237 mL for LH vs 387 mL for OH; P = .049), we found no difference in the rate of perioperative blood transfusion (1 patient [2%] for LH vs 5 [10%] for OH; P = .20). Operative time (219 minutes for LH vs 198 minutes for OH; P = .16), hospital length of stay (5 days for LH vs 6 days for OH; P = .13), and readmission rate (4 patients [8%] for LH vs 5 [10%] for OH; P = .70) were similar in both groups. The rates of major complications (4 patients [8%] for LH vs 4 patients [8%] for OH; P = 10), overall 30-day morbidity (22 patients [42%] for LH vs 19 [37%] for OH; P = .70), and 30-day mortality (1 patient [2%] for LH vs 2 [4%] for OH; P > .99) were not significantly different.

Conclusions and Relevance  Patients who undergo LH have similar short-term outcomes when compared with those who undergo OH. Laparoscopic hepatectomy was associated with lower intraoperative blood loss, although the clinical significance of this finding is uncertain given the lack of difference in perioperative transfusion or morbidity rates. In addition, we found no difference in margin status between the 2 groups. Future studies are needed to define which patients derive benefit from LH and to determine oncologic equivalence to OH.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();