How should one review a potential classic? This book almost certainly will become one, for it is timely and comprehensive, appearing at a time of enormous gains in knowledge and understanding but confusion about management of ductal carcinoma in situ (DCIS), as a result of the marked increase in detection from mammographic screening. Essentially everything known about DCIS is included in this tome of 70 chapters edited by Dr Melvin Silverstein and 3 associate editors. Almost all major authors and studies—retrospective, prospective, and randomized—have been included. There are sections on epidemiology, biological features, prognostic indicators, cytogenetics, cytomorphology, pathology, and radiological diagnostic features of DCIS and related lesions such as atypical intraductal and lobular hyperplasia, DCIS with microinvasion, and Paget disease. Ductal carcinoma in situ is placed in the context of the whole spectrum of abnormalities of the lactiferous duct epithelium and the critical terminal ductal lobular unit.