Correspondence and Brief Communications |

A Randomized Trial of an Antibiotic- and Antiseptic-Coated Central Venous Catheter in the Prevention of Catheter-Related Infections

Alfons Bach, MD
Arch Surg. 1998;133(9):1022. doi:.
Text Size: A A A
Published online


I read with interest the study by Tennenberg et al1 demonstrating that antiseptic-impregnated catheters reduce the risk of catheter-related infection. However, these results may be flawed because the potential impact of residual anti-infective compounds from the coated catheter on the subsequent microbiologic culture was not discussed.

For example, Schmitt et al2demonstrated in an in vitro study that antiseptic compounds elute from catheters during culturing processes. Their findings show that it is critical for all culture techniques to include inhibitors of the antiseptic catheter compounds. Results of a previous study employing inhibitors3 to examine the bacterial colonization on 116 antiseptic-bonded and 117 control catheters showed that all antiseptic catheters retained antibacterial activity in patients for at least 5 days, and some of them for up to 20 days. These findings and the recent report by Maki et al4 demonstrate a long-lasting effect of antiseptic compounds on impregnated catheters. Because these antiseptic compounds may be transferred into the culture media, falsely low bacterial counts may have occurred if Tennenberg et al1 did not add inhibitors to their culture media.

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
PubMed Articles

Users' Guides to the Medical Literature
Clinical Resolution

Users' Guides to the Medical Literature
Clinical Scenario