Robert Douglas Sweet first described Sweet syndrome in 1964.1 In his report, Sweet described 8 patients with a neutrophilic dermatosis associated with acute febrile illnesses.1 Sweet syndrome primarily affects adults 30 to 60 years of age and has a female-male ratio of 3:1. There are 4 subtypes of the syndrome: the classic type (71% of cases) and types associated with neoplasia (11% of cases), inflammatory disease (16% of cases), and pregnancy (2% of cases). The primary lesion is a sharply marginated, tender, erythematous plaque, 2 to 10 cm in diameter, that typically appears as multiple lesions on the face, neck, upper trunk, and extremities. Asymmetry of distribution is common. Onset can be abrupt and lesions may increase in size quickly. In 90% of cases, a significant illness, such as an upper respiratory tract infection, precedes the onset of lesions. Fever, myalgia, arthritis, conjunctivitis, renal involvement, and leukocytosis are common features of the syndrome.2 Sweet syndrome may be associated with hematologic malignancies, although our patient had no evidence of hematologic malignancy or recurrence of colon cancer at the time the rash developed.