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Original Article |

Laparoscopically Treated Liver Hydatid Cysts FREE

Metin Ertem, MD; Tayfun Karahasanoglu, MD; Nihat Yavuz, MD; Sabri Erguney, MD
[+] Author Affiliations

From the Department of General Surgery, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey.


Arch Surg. 2002;137(10):1170-1173. doi:10.1001/archsurg.137.10.1170.
Text Size: A A A
Published online

Hypothesis  Laparoscopy is effective and reliable in treating hepatic hydatid disease.

Design  Case series of patients with hepatic hydatid disease who underwent laparoscopic treatment within 7 years.

Setting  Department of General Surgery, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey.

Patients  Forty-eight patients with hydatid disease who met our criteria for laparoscopic surgery and were aged 17 years or older.

Interventions  Cystotomy and partial cystectomy with drainage were performed in 33 patients. Omentoplasty was simultaneously performed in 15 patients to obliterate the cystic cavity.

Main Outcome Measures  Clinicopathologic features, morbidity, mortality, operative time, length of hospital stay, conversion to laparotomy, and recurrences were reviewed retrospectively.

Results  The mean operative time was 82 minutes (range, 45-170 minutes). The conversion rate to open surgery was 4%. The mean postoperative length of hospital stay was 4.2 days. Morbidity was 6% (3 patients). There was no mortality. The mean follow-up was 34.2 months. No recurrences were observed during this period.

Conclusions  Laparoscopic hepatic hydatid surgery is a safe and effective method in selected patients. Further studies should be encouraged in this field because there is no universally accepted standard technique.

Figures in this Article

IN THE LAST DECADE, laparoscopic treatment of hepatic hydatid disease has been increasingly popular and has undergone a revolution parallel to the progress in laparoscopic surgery. There are encouraging preliminary results; however, there have been limited reports concerning long-term results of this technique.

Preliminary results of 12 patients treated laparoscopically were published in 1998,1 and results of 34 patients were published in 2000.2 With increased use, the technique has been refined and standardized. This study presents our experience, new techniques, and long-term cumulative results in laparoscopic treatment of hepatic hydatid disease.

From January 1, 1994, to February 28, 2001, 48 patients with hepatic hydatid disease were treated laparoscopically in the Department of General Surgery, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey. One of them had undergone conventional surgery 4 years earlier. During the same period, 228 patients with hepatic hydatid disease underwent conventional surgery. The disease was diagnosed by ultrasonography (US) and computed tomography (CT) and confirmed by serological examination.

Our exclusion criteria for laparoscopic intervention included intraparenchymal location of the cyst, more than 3 cysts, or cysts with thick and calcified walls. There were 32 women and 16 men. The mean age was 40.6 years (range, 17-71 years). Although 46 patients had solitary cysts, 1 patient had 2 and another had 3 cysts. The mean cystic diameter was 8 cm (range, 2-18 cm). Eighteen cysts were localized in subsegment VI, 12 in subsegment V, 6 in subsegment VII, 6 in subsegment IV, 5 in subsegment III, and 4 in subsegment VIII.

All procedures were performed in the supine position under endotracheal anesthesia. Antibiotics were administered 30 minutes before the operation. A nasogastric tube was placed, and the urinary bladder was catheterized. Five trocars were placed according to cyst location (Figure 1). Following exposure of the cyst by a 30° telescope inserted through the umbilical trocar, an 11-mm trocar was inserted from a point as close as possible to the cyst. From this trocar, 3 gauzes were introduced into the abdominal cavity, placed around the cyst, and soaked with 10% povidone iodine solution as a scolecidal agent. The cyst was punctured with a 14-gauge 6F aspiration needle. As a precaution, the tip of a 5-mm suction catheter was placed close to the puncture site (Figure 2), and as much cystic fluid as possible was aspirated, so that the endocyst (germinative membrane) detached from the cystic wall and shrank to the bottom of the cyst. The deflated cystic wall was suspended by 2 graspers, and cystotomy was performed. At this stage, the 11-mm trocar was exchanged for an 18-mm one. A transparent tube with a 15-mm internal diameter was inserted through the 18-mm trocar, and the germinative membrane was aspirated (Figure 3). A hose of the same diameter was connected to the transparent tube, and the entire membrane was removed. In all cases, the telescope was inserted into the cyst to explore for potential biliary openings and retained daughter cysts. The cystic cavity was irrigated with 20% hypertonic saline (another scolecidal agent) several times, and unroofing was performed by partial or near-total cystectomy. Omentoplasty was simultaneously performed in suitable cases. In the remaining patients, a drain was placed in the cystic cavity. Gauzes and pieces of the excised cystic wall were placed in an endosac and removed.

Place holder to copy figure label and caption
Figure 1.

Trocar sites.

Graphic Jump Location
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Figure 2.

Schematic view of cyst evacuation.

Graphic Jump Location
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Figure 3.

Aspiration of the germinative membrane.

Graphic Jump Location

Oral liquid intake was started on the first postoperative day. After drain removal, if no bile leakage or major ascites drainage was present, the drain was removed and the patient was discharged. A 3-month course of albendazole (10 mg/kg per day) was administered postoperatively to all patients.

The patients were followed up by US every 3 months during the first year, then by US and CT every 6 months during the second year, and thereafter by US, CT, and serological examinations annually.

Laparoscopic cystotomy and partial cystectomy with drainage were performed in 33 patients, and laparoscopic cystotomy and partial cystectomy with omentoplasty were performed in 15 patients. In 2 patients (4%), laparoscopic procedures were converted to open surgery because of inadequate exposure and access. Other simultaneously performed surgical procedures were cholecystectomy in 4 patients, cholecystectomy and T-tube drainage in 1 patient, and inguinal hernia repair (transabdominal preperitoneal polypropylene meshplasty) in 1 patient. In 1 patient, the cystic fluid was noted to be bile stained, suggesting biliary rupture. We performed choledochotomy and T-tube drainage. On the tenth postoperative day, the drain was removed under controlled T-tube cholangiographic examination.

The mean operative time was 82 minutes (range, 45-170 minutes). There was no mortality. Morbidity was 6.2% (3 patients). Port-side infection occurred in 1 patient. In another patient, bile leakage was observed on the second postoperative day, which was managed by endoscopic sphincterotomy. The leakage gradually ceased within 9 days. This patient was discharged on the twelfth postoperative day. In the third patient, an infected perihepatic hematoma developed after discharge from the hospital. This patient was rehospitalized with pain and high fever (temperature, 39°C), and the collection was drained percutaneously.

The mean length of hospital stay was 4.2 days (range, 3-13 days). The mean follow-up was 34.2 months (range, 4-78 months). Radiological and serological test results showed no recurrences. A recurrence was suspected in 1 patient based on US and CT images in the sixth postoperative month (Figure 4). Laparotomy was performed, and exploration revealed a cystic cavity filled with scolex-free sterile fluid, which was later confirmed microscopically.

Place holder to copy figure label and caption
Figure 4.

Preoperative computed tomographic image.

Graphic Jump Location

Although treatment choices for hydatid disease of the liver have increased in the last 2 decades, including medical treatment, percutaneous drainage, or a combination, surgery remains the mainstay of therapy. Use of these other modalities is restricted to certain stages of the disease and is associated with inconsistent results.37

Total pericystectomy seems to be the best operative procedure for small and peripherally located cysts.8 It has been demonstrated that pericysts contain no scolices.3 For large and deeply located cysts, the more extensive cystectomy and hepatectomy are accompanied by higher morbidity.

We have used laparoscopic techniques in selected patients since 1994, applying the principles of conventional liver hydatid cyst surgery, including inactivation of scolices, prevention of spillage, elimination of viable elements of the cyst, and management of the residual cavity.

A major disadvantage of laparoscopy is the lack of precautionary measures concerning spillage, especially under high abdominal pressures induced by pneumoperitoneum.912 However, Bickel et al13 demonstrated that the increase in intracystic pressure was no greater than the increase in intraabdominal pressure and that the pneumoperitoneum was protective against spillage. We believe that decreasing the pressure of the pneumoperitoneum to avoid possible spillage is not beneficial and is perhaps harmful. The most dangerous step is the initial puncture and aspiration of the cystic fluid, but no less precaution is taken than in conventional surgery, with gauzes soaked with scolecidal agents surrounding the puncture site and the suction catheter on guard.

In the past, we considered cysts with diameters greater than 15 cm and recurrent hydatid disease as exclusion criteria but, with increased experience, no longer do so.1,2 The content of cysts with calcified walls is unlikely to be fertile, and these should be followed up.3

We converted to laparotomy in 2 patients because of unsafe exposure and unsatisfactory access. In both cases, the cysts were located in subsegment VII. We used the supine position in all cases. One report describes the placement of a patient in a lateral position to gain access to a simple cyst of the liver located posterolaterally within segment VII.14 We do not consider the lateral position safe for laparoscopic access to hydatid cysts of the liver.

Some authors do not recommend the use of scolecidal agents because of possible sclerosing cholangitis.15 We believe these are necessary because simple irrigation with isotonic sodium chloride does not ensure the inactivation or clearance of scolices.

Intrabiliary rupture of the cyst is the most common complication of the disease, seen in 5% to 25% of patients.16 In these patients, the ideal technique is choledochotomy, irrigation, and T-tube drainage. However, this procedure prolongs the hospitalization. We found bilious cystic content in 1 patient that had not been recognized preoperatively. We used intraoperative cholangiography to confirm this and performed choledochotomy and T-tube drainage laparoscopically.

Endoscopic sphincterotomy is the first line of treatment for postoperative external biliary fistulas related to treatment of hepatic hydatid disease.17 In 1 patient, we encountered a biliary leakage through the drain on the second postoperative day, which resolved in 10 days following endoscopic sphincterotomy.

Another important issue in laparoscopic hydatid cyst surgery is the removal of the germinative membrane. For this procedure, several techniques and instruments have been described. Alper et al18 use an aspirator-grinder apparatus, and Bickel and Eitan19 recommend the use of a large-bore suction catheter. We use a wide-bore suction catheter without a valvular system, which avoids the narrowing caused by valvular systems.

Marvik et al20 use US in laparoscopic cyst unroofing. We concur that intraoperative US can be useful in detecting the cyst and assessing the structure of the liver.

Because of suspected recurrence, based on US and CT findings, laparotomy was performed in one of our patients (Figure 4). A similar radiological misinterpretation has been reported,21,22 underscoring caution in making premature misdiagnoses. Recurrence should be confirmed by seropositivity and by an observed increase in the size of the cyst during follow-up. It is advisable to wait until the characteristic signs appear before surgical exploration.

The recurrence rate ranges from 3% to 10% following open surgery for hepatic hydatid cysts.23,24 In our laparoscopic series and follow-up, we have not seen any recurrences.

In conclusion, laparoscopic treatment of liver hydatid cyst disease is safe and effective in selected patients and offers all the advantages of laparoscopic surgery. Further studies should be encouraged in this field to determine a universally accepted standard technique.

Corresponding author: Metin Ertem, MD, Department of General Surgery, Cerrahpasa Medical School, University of Istanbul, Istasyon Cad Kemal Kayacan sok 16/3, Goztepe/Istanbul, Turkey (e-mail: mertem@istanbul.edu.tr).

Ertem  MUras  CKarahasanoglu  TErguney  SAlemdaroglu  K Laparoscopic approach to hepatic hydatid disease. Dig Surg. 1998;15333- 336
Link to Article
Ertem  M Our experience with laparoscopic treatment of liver hydatid cyst. Arch Balkan Med Union. 2000;35115- 120
Goksoy  EDuren  M Operative therapiedes Echinococcus granulosus (cysticus). Chirurgia (Bucur). 2000;7121- 29
Link to Article
Aktan  AOYalin  R Preoperative albendazole treatment for liver hydatid disease decreases the viability of the cyst. Eur J Gastroenterol Hepatol. 1996;8877- 879
Aktan  OOzmen  MNDincer  ASayek  IGocmen  A Liver hydatid disease: long-term results of percutaneous treatment. Radiology. 1996;198259- 264
Bastrol  CAzar  CDoyer  MSahal  P Percutaneous treatment of hydatid cysts under sonographic guidance. Dig Dis Sci. 1989;71576- 1580
Adrien  GS Medical treatment of liver hydatidosis. World J Surg. 2001;2515- 20
Link to Article
Guibert  LGayral  F Laparoscopic pericystectomy of a liver hydatid cyst. Surg Endosc. 1995;9442- 443
Terblanche  JKrige  JEJ Hepatic echinococcosis. Cameron  JLed.Current Surgical Therapy 6th ed. London, England Mosby Inc1998;326- 330
Klingler  PJGadenstatter  MSchmid  TBodner  ESchwelberger  HG Treatment of hepatic cysts in the era of laparoscopic surgery. Br J Surg. 1997;84438- 444
Link to Article
Iskender  S Diagnosis and treatment of uncomplicated hydatid cyst of the liver. World J Surg. 2001;2521- 27
Link to Article
Berberoglu  MTaner  SDilek  ONDemir  ASari  S Gasless vs gaseous laparoscopy in the treatment of hepatic hydatid disease. Surg Endosc. 1999;131195- 1198
Link to Article
Bickel  ADaud  GUrbach  DLefler  EBarasch  EFEitan  A Laparoscopic approach to hydatid liver cysts: is it logical? physical, experimental and practical aspects. Surg Endosc. 1998;121073- 1077
Link to Article
Watson  DIJamieson  GG Laparoscopic fenestration of giant posterolateral liver cyst. J Laparoendosc Surg. 1995;5255- 257
Link to Article
Senyuz  OFCelayir  ACKilic  N  et al.  Hydatid disease of the liver in childhood. Pediatr Surg Int. 1999;15217- 220
Link to Article
Alper  AAriogul  OEmre  AUras  AOkten  A Choledochoduodenostomy for intrabiliary rupture of hydatid cysts of liver. Br J Surg. 1987;74243- 245
Link to Article
Tekant  YBilge  KAcarli  KAlper  AEmre  AAriogul  O Endoscopic sphincterotomy in the treatment of postoperative biliary fistulas of hepatic hydatid disease. Surg Endosc. 1996;10909- 911
Link to Article
Alper  AEmre  AAcarli  KBilge  OOzden  IAriogul  O Laparoscopic treatment of hepatic hydatid disease. J Laparoendosc Surg. 1996;629- 33
Link to Article
Bickel  AEitan  A The use of a large, transparent cannula, with a beveled tip, for safe laparoscopic management of hydatid cysts of liver. Surg Endosc. 1995;91304- 1305
Marvic  RMyrvold  HEJohnsen  GRoysland  P Laparoscopic ultrasonography and treatment of hepatic cysts. Surg Laparosc Endosc. 1993;3172- 174
Yalin  ROzdemir  AAcikozoglu  S Computed tomography and sonography of hydatid cysts of the liver after surgical management. J Med Imaging. 1989;3301- 305
Adam  ARoddie  ME Computed tomography of the liver and biliary tract. Blumgart  LHed.Surgery of the Liver and Biliary Tract Edinburgh, Scotland Churchill Livingstone1994;243- 267
Demirci  SEraslan  SAnado  EBozatli  L Comparison of the results of different surgical techniques in the management of hydatid cysts of the liver. World J Surg. 1989;1388- 91
Link to Article
Turkcapar  AGErsoz  SGungor  CAydinuraz  KYerdel  MAAras  N Surgical treatment of hepatic hydatidosis combined with preoperative treatment with albendazole. Eur J Surg. 1997;163923- 928

Figures

Place holder to copy figure label and caption
Figure 1.

Trocar sites.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Schematic view of cyst evacuation.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 3.

Aspiration of the germinative membrane.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 4.

Preoperative computed tomographic image.

Graphic Jump Location

Tables

References

Ertem  MUras  CKarahasanoglu  TErguney  SAlemdaroglu  K Laparoscopic approach to hepatic hydatid disease. Dig Surg. 1998;15333- 336
Link to Article
Ertem  M Our experience with laparoscopic treatment of liver hydatid cyst. Arch Balkan Med Union. 2000;35115- 120
Goksoy  EDuren  M Operative therapiedes Echinococcus granulosus (cysticus). Chirurgia (Bucur). 2000;7121- 29
Link to Article
Aktan  AOYalin  R Preoperative albendazole treatment for liver hydatid disease decreases the viability of the cyst. Eur J Gastroenterol Hepatol. 1996;8877- 879
Aktan  OOzmen  MNDincer  ASayek  IGocmen  A Liver hydatid disease: long-term results of percutaneous treatment. Radiology. 1996;198259- 264
Bastrol  CAzar  CDoyer  MSahal  P Percutaneous treatment of hydatid cysts under sonographic guidance. Dig Dis Sci. 1989;71576- 1580
Adrien  GS Medical treatment of liver hydatidosis. World J Surg. 2001;2515- 20
Link to Article
Guibert  LGayral  F Laparoscopic pericystectomy of a liver hydatid cyst. Surg Endosc. 1995;9442- 443
Terblanche  JKrige  JEJ Hepatic echinococcosis. Cameron  JLed.Current Surgical Therapy 6th ed. London, England Mosby Inc1998;326- 330
Klingler  PJGadenstatter  MSchmid  TBodner  ESchwelberger  HG Treatment of hepatic cysts in the era of laparoscopic surgery. Br J Surg. 1997;84438- 444
Link to Article
Iskender  S Diagnosis and treatment of uncomplicated hydatid cyst of the liver. World J Surg. 2001;2521- 27
Link to Article
Berberoglu  MTaner  SDilek  ONDemir  ASari  S Gasless vs gaseous laparoscopy in the treatment of hepatic hydatid disease. Surg Endosc. 1999;131195- 1198
Link to Article
Bickel  ADaud  GUrbach  DLefler  EBarasch  EFEitan  A Laparoscopic approach to hydatid liver cysts: is it logical? physical, experimental and practical aspects. Surg Endosc. 1998;121073- 1077
Link to Article
Watson  DIJamieson  GG Laparoscopic fenestration of giant posterolateral liver cyst. J Laparoendosc Surg. 1995;5255- 257
Link to Article
Senyuz  OFCelayir  ACKilic  N  et al.  Hydatid disease of the liver in childhood. Pediatr Surg Int. 1999;15217- 220
Link to Article
Alper  AAriogul  OEmre  AUras  AOkten  A Choledochoduodenostomy for intrabiliary rupture of hydatid cysts of liver. Br J Surg. 1987;74243- 245
Link to Article
Tekant  YBilge  KAcarli  KAlper  AEmre  AAriogul  O Endoscopic sphincterotomy in the treatment of postoperative biliary fistulas of hepatic hydatid disease. Surg Endosc. 1996;10909- 911
Link to Article
Alper  AEmre  AAcarli  KBilge  OOzden  IAriogul  O Laparoscopic treatment of hepatic hydatid disease. J Laparoendosc Surg. 1996;629- 33
Link to Article
Bickel  AEitan  A The use of a large, transparent cannula, with a beveled tip, for safe laparoscopic management of hydatid cysts of liver. Surg Endosc. 1995;91304- 1305
Marvic  RMyrvold  HEJohnsen  GRoysland  P Laparoscopic ultrasonography and treatment of hepatic cysts. Surg Laparosc Endosc. 1993;3172- 174
Yalin  ROzdemir  AAcikozoglu  S Computed tomography and sonography of hydatid cysts of the liver after surgical management. J Med Imaging. 1989;3301- 305
Adam  ARoddie  ME Computed tomography of the liver and biliary tract. Blumgart  LHed.Surgery of the Liver and Biliary Tract Edinburgh, Scotland Churchill Livingstone1994;243- 267
Demirci  SEraslan  SAnado  EBozatli  L Comparison of the results of different surgical techniques in the management of hydatid cysts of the liver. World J Surg. 1989;1388- 91
Link to Article
Turkcapar  AGErsoz  SGungor  CAydinuraz  KYerdel  MAAras  N Surgical treatment of hepatic hydatidosis combined with preoperative treatment with albendazole. Eur J Surg. 1997;163923- 928

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