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Comment & Response |

Effect of Breast Cancer After Ovarian Cancer on Mortality for BRCA Mutation Carriers

Alexander Liede, MSc, PhD1; Ping Sun, PhD2; Steven Narod, MD, FRCPC2
[+] Author Affiliations
1Center for Observational Research, Amgen Inc, South San Francisco, California
2Women’s College Research Institute, Toronto, Ontario, Canada
JAMA Surg. 2015;150(5):490-491. doi:10.1001/jamasurg.2015.0193.
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To the Editor Gangi et al1 describe survival among a cohort of 364 women who received a diagnosis of epithelial ovarian cancer with up to 14 years of follow-up (median follow-up, 5.1 years). They conclude that women with a BRCA1 or BRCA2 mutation (37% of the women in their sample) who subsequently develop breast cancer have a higher survival rate than those who do not. We are concerned that the conclusions regarding survival are subject to immortal time bias.


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May 1, 2015
Alexandra Gangi, MD; Galinos Baramparas, MD; Farin F. Amersi, MD
1Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California
JAMA Surg. 2015;150(5):491-492. doi:10.1001/jamasurg.2015.0196.
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