0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Invited Commentary |

The Biology Behind the American College of Surgeons Oncology Group Z0011 Trial

Kimberly Stone, MD1; Amanda J. Wheeler, MD1
[+] Author Affiliations
1Department of Surgery, Stanford University School of Medicine, Palo Alto, California
JAMA Surg. 2015;150(12):1148-1149. doi:10.1001/jamasurg.2015.1716.
Text Size: A A A
Published online

Extract

Sentinel lymph node biopsy has been widely adopted as the standard of care in assessing the axilla for the presence of lymph node metastases in patients diagnosed as having breast cancer.1

The American College of Surgeons Oncology Group Z0011 trial has established a low rate of locoregional recurrence with the omission of axillary lymph node dissection (ALND), with the adjunct of improved systemic therapy as well as radiation therapy in patients with minimal nodal disease. Gross extranodal disease was excluded but microscopic extranodal extension (ENE) was not evaluated. The trial did, however, include lymphovascular invasion with 35.2% in the sentinel lymph node biopsy arm vs 40.6% in the axillary lymph node dissection arm; like ENE, lymphovascular invasion is a poor prognostic indicator.2

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

342 Views
0 Citations
×

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();