We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Research Letter |

Addition of Statins to Treatment With β-Blockers to Improve Outcomes for Cardiac Surgery Patients Beyond the Surgical Care Improvement Project

William Toppen, BA1; Sohail Sareh, MS1; Daniel Johansen, BA1; Bradley Genovese, MD; Nancy Satou, RN1; Richard Shemin, MD1; Peyman Benharash, MD1
[+] Author Affiliations
1Division of Cardiac Surgery, David Geffen School of Medicine at University of California, Los Angeles
JAMA Surg. 2016;151(4):389-391. doi:10.1001/jamasurg.2015.4212.
Text Size: A A A
Published online


This study reports on whether treatment with β-blockers, statins, or both before cardiac surgery is associated with a reduction in the risk of adverse events after surgery.

For nearly 2 decades, β-blockers have been thought to reduce the risk of major adverse cardiovascular events during the perioperative period. Beginning with the Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography trial1 in 1999, a series of studies have provided compelling evidence that patients undergoing high-risk operations should receive β-blockers before surgery.2 Given these findings, the Surgical Care Improvement Project required that all patients previously receiving β-blockers should receive their medication in the 24 hours before surgery. More recently, however, several large-scale studies have failed to reproduce these beneficial effects,3,4 and the Perioperative Ischemic Evaluation trial4 found increased mortality with the use of β-blockers before surgery.

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles