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Comment & Response |

Risk-Reduction Program for Cardiovascular and Limb Events in Patients With Peripheral Arterial Disease—Reply ONLINE FIRST

Mohamad A. Hussain, MD1; Mohammed Al-Omran, MD, MSc1,2,3; Thomas F. Lindsay, MDCM, MSc1,4
[+] Author Affiliations
1Department of Surgery, University of Toronto, Toronto, Ontario, Canada
2Division of Vascular Surgery, Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario, Canada
3King Saud University–Li Ka Shing Collaborative Research Program and Department of Surgery, King Saud University, Riyadh, Saudi Arabia
4Division of Vascular Surgery, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada
JAMA Surg. Published online August 03, 2016. doi:10.1001/jamasurg.2016.2260
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In Reply Dr Kawada correctly recognized that we did not observe an improvement in the overall mean body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) of patients with peripheral arterial disease (PAD) enrolled in a risk-reduction program (mean [SD] BMI, 27.2 [3.6] at baseline vs 27.2 [5.6] at follow-up; mean difference, 0.0 [95% CI, −1.9 to 2.15]; P = .71).1 However, to contextualize this finding in a more clinically relevant manner, we converted BMI into a categorical variable based on the standard definitions of overweight (BMI ≥ 25) vs target weight (BMI < 25). We found that the proportion of patients who met the target BMI increased from 27% at baseline to 38% at follow-up, a significant difference (P = .05). Therefore, it appears that a subset of patients enrolled in the risk-reduction program were able to lose enough weight to meet their target BMI at follow-up.


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August 3, 2016
Tomoyuki Kawada, MD, PhD
1Department of Hygiene and Public Health, Nippon Medical School, Bunkyo-ku, Tokyo, Japan
JAMA Surg. Published online August 03, 2016.;():. doi:10.1001/jamasurg.2016.2257.
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