0
Correspondence and Brief Communications |

Is the p53 Gene Mutation of Prognostic Value in Hepatocellular Carcinoma?

Irene Oi-Lin Ng, MD, FRCPath; Sheung-Tat Fan, MS, MD, FRCS (Edin and Glasg)
Arch Surg. 2000;135(12):1476. doi:10.1001/archsurg.135.12.1476.
Text Size: A A A
Published online

Extract

The prognostic value of p53 overexpression in hepatocellular carcinoma (HCC) is controversial. It has been reported that p53 protein overexpression is associated with a poorer prognosis in terms of patients' survival.1 Jeng et al2 report a significant association of p53 overexpression with a more invasive phenotype of the tumor and higher rates of recurrence, but the survival lengths were not significantly affected. In other studies, p53 overexpression in HCC has also been associated with more aggressive behavior of the tumor, poorer cellular differentiation, venous permeation, and intrahepatic metastasis.3 These and other data4,5 imply that p53 overexpression plays a significant role in tumor progression, particularly at a later stage of hepatocarcinogenesis. However, in some reports with either univariate or multivariate analysis,6,7p53 overexpression in HCC has not been found to have prognostic significance despite the finding that tumors with p53 overexpression often had more malignant characteristics. Interestingly, the controversy of prognostic significance is not confined to p53 protein in HCC tissue but is also seen with serum anti-p53. It has been found that the presence of serum anti-p53 is related to both poor8 and positive prognoses,9 with longer disease-free survival.

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 2

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
PubMed Articles
Jobs
brightcove.createExperiences();