A 52-YEAR-OLD man underwent living unrelated donor renal transplantation for treatment of end-stage renal disease caused by congenital obstructive disease. Immunosuppression was initiated with 2 doses of simulect and maintained with cyclosporine microemulsion, mycophenolic acid, and prednisone. The allograft functioned immediately, and there were no rejection episodes. Thirteen months later, the patient complained of severe itching, malaise, and anorexia. Physical examination revealed diffuse excoriations and deep jaundice. Laboratory values included awhite blood cell count of 5.4 × 103/µL, serum creatinine level of 1.9 mg/dL (158 µmol/L), total bilirubin level of 15.2 mg/dL (260 µmol/L), direct bilirubin level of 12.4 mg/dL (212 µmol/L), alanine aminotransferase of 270 U/L, aspartate aminotransferase of 329 UL, and alkaline phosphatase of 1090 U/L. Images from the computed tomography and magnetic resonance imaging scans are shown in Figure 1 and Figure 2.