If the genetic message (mRNA) is so unstable, the opportunity for posttranscriptional regulation by modification and stabilization of the mRNA should be huge—and it is. Recently, a family of RNA that is not classified as mRNA, transfer RNA, or ribosomal RNA, has been identified.2 This was initially termed other RNA. It is now termed ncRNA. Some are short, consisting of 21- to 25-nucleotide segments, and are sometimes referred to as micro-RNA. Other larger ncRNA appear to influence protein structure and function by regulating transcription, RNA processing, RNA modification, and RNA stability.2 Following protein synthesis, ncRNAs also provide posttranslational regulation by influencing protein stability and translocation.3 Intuitively, ncRNA and, presumably, nonfunctioning RNA should not be conserved through evolution. In this instance, our intuition is correct. These small bits of ncRNA seem to do a lot.