We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Invited Response |

Decreased Inflammation and Improved Survival With Recombinant Human Activated Protein C Treatment in Experimental Acute Pancreatitis—Invited Response

Guido Alsfasser, MD; Andrew L. Warshaw, MD; Carlos Fernández-del Castillo, MD
Arch Surg. 2006;141(7):677. doi:10.1001/archsurg.141.7.677.
Text Size: A A A
Published online


In the 15 years since we first described our pancreatitis model,1 we have performed dozens of experimental studies related to its pathogenesis and treatment and have never before encountered an intervention with such a dramatic effect in the early phases of the disease. It is not only that we found a significantly improved 24-hour survival, but also that surviving rats (almost the entire treatment group) appeared remarkably healthier. We were surprised when evaluation of the pancreas showed no difference between controls and treated rats, and from there we assume the improvement related to less lung injury, which is the earliest and most common form of organ failure associated with pancreatitis. This hypothesis is backed by the almost complete normalization of myeloperoxidase concentration in lungs. Myeloperoxidase has been found by us and other investigators2,3 to correlate very closely with both leukocyte infiltration and histologic lung injury.

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections