A 61-year-old Filipino woman had a recent episode of syncope and unintentional weight loss noted over a 6-month period. On physical examination, she was found to be tachycardic and to have a large necrotic mass in her right breast (Figure 1). Laboratory findings were notable for anemia with a hematocrit value of 19%. A fine-needle aspiration biopsy of the mass showed only cellular stromal fragments with no cytological atypia. Chest computed tomography showed a 21 × 18-cm, smooth-contoured, heterogeneous chest wall mass with no obvious chest wall invasion (Figure 2).