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Section Editor: S. Rozycki Grace, MD

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Arch Surg. 2007;142(9):902. doi:10.1001/archsurg.142.9.902.
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Over the last 15 years, better understanding of the relationship between colorectal polyps and colorectal cancer has challenged the traditional neoplastic pathway from adenoma to carcinoma.1Historically, clinicians have considered hyperplastic polyps to have no malignant potential. However, in 1990, pathologists Longacre and Fenoglio-Preiser2described mixed hyperplastic adenomatous polyps that demonstrated serrated glands with varying degrees of dysplasia. These so-called serrated adenomas were identified throughout the colon, sometimes in association with hyperplastic polyposis and frank carcinoma. Most serrated adenomas are in the sigmoid (20%) and rectum (33%), with a prevalence of 1% to 7% at colonoscopy.3,4Studies of their morphology and classification have led investigators to propose a “serrated neoplasia pathway.”5,6

Serrated adenomatous polyposis was described by Torlakovic and Snover7in patients with putative hyperplastic polyposis with or without carcinoma. Endoscopic examination revealed sheets of colorectal polyps consistent with familial adenomatous polyposis (FAP), but pathologic examination showed apparent hyperplasia and morphologic evidence of serrated adenoma. Torlakovic and Snover noted that 47% of cases of hyperplastic/metaplastic polyposis in the literature were associated with adenocarcinoma, giving credence to the hypothesis that serrated adenomas are premalignant lesions. Because our 57-year-old patient had biopsy-proven serrated adenoma, endoscopic evidence of more than 100 polyps, and no family history of FAP, the most reasonable diagnosis was serrated adenomatous polyposis.

With the sporadic loss of the second copy of the tumor suppression gene adenomatous polyposis coli, patients with FAP develop multiple adenomatous polyps (>100), usually with progression to colorectal carcinoma by their late thirties.1In addition, these patients are at risk for extracolonic neoplasms.1,6Patients with FAP have a low incidence of serrated adenoma (2.2% of biopsied polyps) and are more likely to have tubular adenoma (83%).8

Hereditary nonpolyposis colorectal cancer syndrome tends to occur in patients in their fifth decade who do not have polyposis (<100 polyps). With 1 defective DNA mismatch gene already, these patients develop colorectal cancer when they acquire mutations in the second copy of mismatch repair genes, which results in accumulation of genomic mutations.1

Hereditary mixed polyposis syndrome, an autosomal dominant disease with high penetrance, is associated with increased risk of colorectal cancer. Hereditary mixed polyposis syndrome was identified initially in a large Ashkenazi Jewish family in 1989.9Patients usually have fewer than 15 colon polyps at initial colonoscopy, with different histological subtypes that include serrated adenoma. These patients present with their first polyp at a mean age of 28 years; colorectal cancer is diagnosed in the fifth or sixth decade of life.

Changing opinions regarding potentially premalignant colorectal polyps have generated several recommendations for the clinician. Closer surveillance is indicated for patients with hyperplastic-appearing polyps larger than 1 cm, more than 20 hyperplastic polyps (especially in a proximal location), or polyps associated with dysplasia. In addition, mixed polyps, serrated adenomas, sessile serrated polyps, or sessile serrated adenomas should be completely excised via colonoscopy, and the patient should undergo close surveillance.10

Correspondence:Anton J. Bilchik, MD, PhD, John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, CA 90404 (bilchika@jwci.org).

Accepted for Publication:September 7, 2006.

Author Contributions:Study concept and design: Kavanagh. Acquisition of data: Kavanagh, Amadpour, and Bilchik. Analysis and interpretation of data: Ahmad. Drafting of the manuscript: Kavanagh. Critical revision of the manuscript for important intellectual content: Ahmad, Amadpour, and Bilchik. Administrative, technical, and material support: Kavanagh and Ahmad. Study supervision: Bilchik.

Financial Disclosure:None reported.

Funding/Support:This work was supported by funding from the Rod Fasone Memorial Cancer Fund, Indianapolis, Indiana; the Henry L. Guenther Foundation, Los Angeles, California; the William Randolph Hearst Foundation, San Francisco, California; the Davidow Charitable Fund, Los Angeles; The Point Grey Charitable Trust, Gary Coull Trustee, Hong Kong, China; and Mr and Mrs Sheldon E. Stunkel and Carolyn Dirks, Los Angeles.

Burgart  LJ Colorectal polyps and other precursor lesions: need for an expanded view. Gastroenterol Clin North Am 2002;31 (4) 959- 970
PubMed Link to Article
Longacre  TAFenoglio-Preiser  CM Mixed hyperplastic adenomatous polyps/serrated adenoma: a distinct form of colorectal neoplasia. Am J Surg Pathol 1990;14 (6) 524- 537
PubMed Link to Article
Chandra  ASheikh  AACerar  A  et al.  Clinico-pathological aspects of colorectal serrated adenomas. World J Gastroenterol 2006;12 (17) 2770- 2772
PubMed
Jaramillo  EWatanabe  MRubio  C  et al.  Small colorectal serrated adenomas: endoscopic findings. Endoscopy 1997;29 (1) 1- 3
PubMed Link to Article
Torlakovic  ESkovlund  ESnover  DC  et al.  Morphologic reappraisal of serrated polyps. Am J Surg Pathol 2003;27 (1) 65- 81
PubMed Link to Article
Jass  JR Serrated route to colorectal cancer: back street or super highway? J Pathol 2001;193 (3) 283- 285
PubMed Link to Article
Torlakovic  ESnover  DC Serrated adenomatous polyposis in humans. Gastroenterology 1996;110 (3) 748- 755
PubMed Link to Article
Matsumoto  TIida  MKobori  Y  et al.  Serrated adenoma in familial adenomatous polyposis: relation to germline APC gene mutation. Gut 2002;50 (3) 402- 404
PubMed Link to Article
Rozen  PSamuel  ZBrazowski  E A prospective study of the clinical, genetic, screening, and pathologic features of a family with hereditary mixed polyposis syndrome. Am J Gastroenterol 2003;98 (10) 2317- 2320
PubMed Link to Article
Cunningham  KSRiddell  RH Serrated mucosal lesions of the colorectum. Curr Opin Gastroenterol 2006;22 (1) 48- 53
PubMed Link to Article

Figures

Tables

References

Burgart  LJ Colorectal polyps and other precursor lesions: need for an expanded view. Gastroenterol Clin North Am 2002;31 (4) 959- 970
PubMed Link to Article
Longacre  TAFenoglio-Preiser  CM Mixed hyperplastic adenomatous polyps/serrated adenoma: a distinct form of colorectal neoplasia. Am J Surg Pathol 1990;14 (6) 524- 537
PubMed Link to Article
Chandra  ASheikh  AACerar  A  et al.  Clinico-pathological aspects of colorectal serrated adenomas. World J Gastroenterol 2006;12 (17) 2770- 2772
PubMed
Jaramillo  EWatanabe  MRubio  C  et al.  Small colorectal serrated adenomas: endoscopic findings. Endoscopy 1997;29 (1) 1- 3
PubMed Link to Article
Torlakovic  ESkovlund  ESnover  DC  et al.  Morphologic reappraisal of serrated polyps. Am J Surg Pathol 2003;27 (1) 65- 81
PubMed Link to Article
Jass  JR Serrated route to colorectal cancer: back street or super highway? J Pathol 2001;193 (3) 283- 285
PubMed Link to Article
Torlakovic  ESnover  DC Serrated adenomatous polyposis in humans. Gastroenterology 1996;110 (3) 748- 755
PubMed Link to Article
Matsumoto  TIida  MKobori  Y  et al.  Serrated adenoma in familial adenomatous polyposis: relation to germline APC gene mutation. Gut 2002;50 (3) 402- 404
PubMed Link to Article
Rozen  PSamuel  ZBrazowski  E A prospective study of the clinical, genetic, screening, and pathologic features of a family with hereditary mixed polyposis syndrome. Am J Gastroenterol 2003;98 (10) 2317- 2320
PubMed Link to Article
Cunningham  KSRiddell  RH Serrated mucosal lesions of the colorectum. Curr Opin Gastroenterol 2006;22 (1) 48- 53
PubMed Link to Article

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