0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Correspondence |

Preconditioning or Postconditioning in Hepatic Surgery—Reply

Giorgio Ercolani, MD, PhD
Arch Surg. 2008;143(10):1026. doi:10.1001/archsurg.143.10.1026-b.
Text Size: A A A
Published online

Extract

In reply

I would like to thank Drs Sadat and Varty for their comments. As they pointed out, ischemic preconditioning was proposed in 1986 by Murry and colleagues1 to reduce ischemia-reperfusion injury. However, it has only been applied to liver surgery in the last decade after the experimental and human studies reported by Selzner et al2 and Clavien et al.3 The hypothesis of a beneficial effect is that ischemic preconditioning can reduce the apoptosis in the hepatic cells and induce development of natural defense mechanisms.3 In the most recent review, Clavien et al3 reported that ischemic preconditioning and intermittent clamping are equally effective in minimizing postoperative liver injury and that intermittent clamping is even superior when total ischemia is longer than 75 minutes.3

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();