A female hepatitis B carrier, aged 35 years, had received regular liver screenings by ultrasonography. It had been noted for several years that the gallbladder was difficult to locate, and contracted gallbladder was presumed. More recently, a palpable mass of about 5 cm was detected at the right periumbilical area. Hepatic hilar lymphadenopathy was suspected following ultrasonography. The laboratory data were normal. Further ultrasonography revealed a target mass approximately 4 cm between the liver, right kidney, and duodenal gas. The corresponding enhanced axial computed tomographic scans revealed a hypodense mass with central rim enhancement (Figure 1). The reconstructed coronal computed tomographic images revealed a large gallbladder mass with markedly thickened walls and hypertrophic mucosa. Magnetic resonance imaging clearly demonstrated multiple small cystic lesions within the hypertrophic wall and surrounding the contracted lumen. The gross pathologic specimen is shown in Figure 2.