Author Contributions:Study concept and design: Alabbas and Kandil. Acquisition of data: Wassef, Chiu, and Kandil. Analysis and interpretation of data: Wassef and Kandil. Drafting of the manuscript: Wassef. Critical revision of the manuscript for important intellectual content: Chiu, Alabbas, and Kandil. Administrative, technical, and material support: Alabbas and Kandil. Study supervision: Kandil.