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Arch Surg. 2011;146(2):238. doi:10.1001/archsurg.2010.339-b.
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ANSWER: HEPATIC CALCIFYING FIBROUS PSEUDOTUMOR

We report the first case, to our knowledge, of calcifying fibrous pseudotumor (CFP) arising in the liver. The first report of benign lesions characterized by fibrocollagenous tissue with dystrophic calcifications and a variable inflammatory infiltrate was made in 1988 by Rosenthal and Abdul-Karim1; a few years later, Fetsch et al2 renamed it calcifying fibrous pseudotumor. A possible relationship with inflammatory myofibroblastic tumors has been proposed as an etiological mechanism, but recent evidence has rejected this hypothesis because of the different immunostaining patterns.3 The CFPs are characterized by negative staining results for anaplastic lymphoma kinase protein, S-100 protein, smooth muscle actin, desmin, CD34, and CD117 (c-kit).3

Most CFPs reported in the literature occurred in women. Saglam et al4 described a young woman with CFP nodules speared throughout the pelvic peritoneum in association with small foci of endometriosis, suggesting that female hormones may play a role in the pathogenesis of CFP. Single or multiple CFPs occur more commonly in subcutaneous and deep soft tissues of the trunk, limbs, and neck and in serosal membranes such as pleura, pericardium, and peritoneum. However, CFP has been reported in unusual sites such as the spermatic cord, the epididymis, and the orbit. Clinically, CFP can be symptomatic or asymptomatic. Symptoms include vague abdominal discomfort, long-lasting pain due to the compression of neighboring structures, and acute abdominal pain due to peritonitis.5 Preoperative diagnosis of CFP is difficult not only owing to its rarity but particularly for the absence of pathognomonic radiological signs. In most cases, CFPs appear as a solid mass with scattered atypical calcifications on computed tomography or magnetic resonance imaging. In our case, the preoperative computed tomographic scan showed a single large mass of heterogeneous attenuation with extensive spherical and clustered calcifications. The magnetic resonance image demonstrated a well-circumscribed tumor with signal intensity suggesting fibrosis and high collagen content. Such radiological findings were confirmed by the final histology, which showed a well-circumscribed tumor composed of fibrocollagenous tissue and several dystrophic calcifications. Therefore, the differential diagnosis should consider calcifying liver metastasis from pulmonary, colorectal, ovarian, mammary, gastric, or prostatic cancers, melanoma, mesenchymal hepatic tumors, hepatic gastrointestinal stromal tumors, some forms of intrahepatic cholangiocarcinoma, hepatic adenoma, or focal nodular hyperplasia. In our case, based on the radiological characteristics (on magnetic resonance imaging particularly), the diagnosis of fibrolamellar carcinoma was made, justifying surgical excision with lymphadenectomy.

The CFP is considered a benign tumor. Several reports indicate a favorable clinical course, but recurrence, even if unusual, has been reported.2,3,6,7

In conclusion, we show that CFP can occasionally occur in the liver. Therefore, differential diagnosis of solid hepatic tumors with calcifications should include CFPs. Surgical resection with clear margins seems indicated owing to the risk of local recurrence.

Return to Quiz Case.

Correspondence: Philippe Bachellier, MD, PhD, Centre de Chirurgie Viscérale et de Transplantation, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Université Louis Pasteur, Avenue Molière, 67200 Strasbourg, France (philippe.bachellier@chru-strasbourg.fr).

Accepted for Publication: November 3, 2009.

Author Contributions:Study concept and design: Rosso. Acquisition of data: Nobili. Analysis and interpretation of data: Rosso, Oussoultzoglou, Casnedi, Jaeck, and Bachellier. Drafting of the manuscript: Nobili, Rosso, Oussoultzoglou, and Casnedi. Critical revision of the manuscript for important intellectual content: Rosso, Oussoultzoglou, Jaeck, and Bachellier. Study supervision: Oussoultzoglou, Jaeck, and Bachellier.

Financial Disclosure: None reported.

Rosenthal  NSAbdul-Karim  FW Childhood fibrous tumor with psammoma bodies: clinicopathologic features in two cases. Arch Pathol Lab Med 1988;112 (8) 798- 800
PubMed
Fetsch  JFMontgomery  EAMeis  JM Calcifying fibrous pseudotumor. Am J Surg Pathol 1993;17 (5) 502- 508
PubMed Link to Article
Nascimento  AFRuiz  RHornick  JLFletcher  CD Calcifying fibrous “pseudotumor”: clinicopathologic study of 15 cases and analysis of its relationship to inflammatory myofibroblastic tumor. Int J Surg Pathol 2002;10 (3) 189- 196
PubMed Link to Article
Saglam  EAUsubütün  AKart  CAyhan  AKüçükali  T Reactive nodular fibrous pseudotumor involving the pelvic and abdominal cavity: a case report and review of literature. Virchows Arch 2005;447 (5) 879- 882
PubMed Link to Article
Ben-Izhak  OItin  LFeuchtwanger  ZLifschitz-Mercer  BCzernobilsky  B Calcifying fibrous pseudotumor of mesentery presenting with acute peritonitis: case report with immunohistochemical study and review of literature. Int J Surg Pathol 2001;9 (3) 249- 253
PubMed Link to Article
Hill  KAGonzalez-Crussi  FChou  PM Calcifying fibrous pseudotumor vs inflammatory myofibroblastic tumor: a histological and immunohistochemical comparison. Mod Pathol 2001;14 (8) 784- 790
PubMed Link to Article
Maeda  AKawabata  KKusuzaki  K Rapid recurrence of calcifying fibrous pseudotumor (a case report). Anticancer Res 2002;22 (3) 1795- 1797
PubMed

Figures

Tables

References

Rosenthal  NSAbdul-Karim  FW Childhood fibrous tumor with psammoma bodies: clinicopathologic features in two cases. Arch Pathol Lab Med 1988;112 (8) 798- 800
PubMed
Fetsch  JFMontgomery  EAMeis  JM Calcifying fibrous pseudotumor. Am J Surg Pathol 1993;17 (5) 502- 508
PubMed Link to Article
Nascimento  AFRuiz  RHornick  JLFletcher  CD Calcifying fibrous “pseudotumor”: clinicopathologic study of 15 cases and analysis of its relationship to inflammatory myofibroblastic tumor. Int J Surg Pathol 2002;10 (3) 189- 196
PubMed Link to Article
Saglam  EAUsubütün  AKart  CAyhan  AKüçükali  T Reactive nodular fibrous pseudotumor involving the pelvic and abdominal cavity: a case report and review of literature. Virchows Arch 2005;447 (5) 879- 882
PubMed Link to Article
Ben-Izhak  OItin  LFeuchtwanger  ZLifschitz-Mercer  BCzernobilsky  B Calcifying fibrous pseudotumor of mesentery presenting with acute peritonitis: case report with immunohistochemical study and review of literature. Int J Surg Pathol 2001;9 (3) 249- 253
PubMed Link to Article
Hill  KAGonzalez-Crussi  FChou  PM Calcifying fibrous pseudotumor vs inflammatory myofibroblastic tumor: a histological and immunohistochemical comparison. Mod Pathol 2001;14 (8) 784- 790
PubMed Link to Article
Maeda  AKawabata  KKusuzaki  K Rapid recurrence of calcifying fibrous pseudotumor (a case report). Anticancer Res 2002;22 (3) 1795- 1797
PubMed

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