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Arch Surg. 2011;146(4):486. doi:10.1001/archsurg.2011.51-b.
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During the laparoscopic cholecystectomy (LC) 3 years earlier for acute gangrenous cholecystitis, gallstones had spilled and all were thought to have been retrieved. The retained pigmented gallstone was not identified on the original CT scan or on the US image but was discovered deep-seated in the necrotic tissue during open debridement of the retroperitoneal abscess. On rereview of the CT scan, a 5-mm enhancing round artifact was noted (Figure 2).

Place holder to copy figure label and caption
Figure 2.

After open debridement of the retroperitoneal abscess and discovery of the retained gallstone, a 5-mm enhancing round artifact (arrow) is noted on the computed tomographic scan.

Graphic Jump Location

Since the introduction of LC1,2 queries have emerged concerning the full spectrum of associated complications with reported overall morbidity of 2% to 11%.3 Gallbladder perforation and spillage of gallstones into the peritoneal cavity are the most common complications during LC, with incidences ranging from 20% to 40%.4,5 Gallstones are retained 1% to 13% of the time, and complications develop in 0.08% to 2.9% of cases.6,7 The risk factors for complications secondary to spilled gallstones are acute cholecystitis with infected bile, pigment gallstones, multiple gallstones (>15), gallstone size (>1.5 cm), and age.8

The mechanism by which gallstones cause abscess formation is not completely understood. Bacterial contamination in pigment stones will more often cause abscess than will cholesterol stones. One hypothesis is that bacteria, in addition to being a source of β-glucuronidase, make up a significant portion of gallstones and facilitate pigment gallstone formation. The gallstone matrix protects the bacteria from antimicrobial factors, which explains the increased incidence of late abscess in pigment gallstone gallbladder disease.9

Avoiding gallstone spillage is the best way to prevent abscess formation. It is helpful to decompress the gallbladder; gentle traction and proper dissection are also required. The use of atraumatic graspers without teeth will decrease the incidence of tearing the gallbladder wall. When a tear is recognized, a suction cannula can be introduced into the gallbladder lumen through the tear for aspiration of the remaining contents. Control of the rent with a pretied suture ligature, hemoclip, or grasper should be considered. As many gallstones as possible should immediately be carefully removed by the use of laparoscopic forceps, an intra-abdominal retrieval bag, a 10-mm suction device, or a “shuttle” gallstone collector.10 The abdomen can be irrigated to dilute the spilled bile. In the case of acute or gangrenous cholecystitis, a drain should be considered.11 Perioperative antibiotic treatment in an attempt to sterilize the surrounding tissue is also recommended in the hope that the missed gallstones will cause adhesions rather than abscesses.12

Complications of gallstones can occur months or even years after LC. Computed tomography is considered the most valuable imaging tool because it is capable of depicting the extent of the inflammatory process and the presence of calcifications consistent with gallstones.12 Retrieval of lost gallstones, as well as drainage or irrigation of abscess cavities, is paramount. Options include interventional laparoscopic radiology and laparotomy. Abscess drainage without gallstone removal should be avoided because it will often result in ongoing clinical problems, such as recurrent abscess formation. Meticulous documentation of gallbladder rupture and gallstone spillage and retrieval should always be given in the operative report.

Return to Quiz Case.

Correspondence: Miral Amin, MD, General Surgery Residency Program, Division of General Surgery, St. Joseph Mercy Oakland, 44405 Woodward Ave, Pontiac, MI 48341 (drmiral80@yahoo.com).

Accepted for Publication: January 12, 2011.

Author Contributions:Study concept and design: Amin and Robinson. Acquisition of data: Amin and Liquete. Analysis and interpretation of data: Amin, Liquete, and Braddock. Drafting of the manuscript: Amin, Liquete, and Robinson. Critical revision of the manuscript for important intellectual content: Amin, Braddock, and Robinson. Administrative, technical, and material support: Robinson. Study supervision: Braddock and Robinson.

Financial Disclosure: None reported.

Birkett  DH Spilled cells, spilled clips, spilled stones. Surg Endosc 1995;9 (3) 269- 271
PubMed
Birkett  DHBirkett  DH Biliary tract.  In: Townsend CM, Beauchamp  RD, Evers  BM, Mattox  K, eds. Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice.17th ed. Philadelphia, PA: WB Saunders Co; 2004:1612-1614
Birkett  DHBirkett  DHBirkett  DH Complications of therapeutic laparoscopy. Curr Probl Surg 1994;31 (11) 857- 924
PubMed
Birkett  DHBirkett  DHBirkett  DH  et al Is the loss of gallstones during laparoscopic cholecystectomy an underestimated complication? Surg Endosc2000144373374 doi:10.1007/PL00013416
Birkett  DHBirkett  DHBirkett  DHFitzgibbons  RJ  Jr The outcome of unretrieved gallstones in the peritoneal cavity during laparoscopic cholecystectomy: a prospective analysis. Surg Endosc 1999;13 (9) 848- 857
PubMed
Birkett  DHBirkett  DHBirkett  DH  et al.  Long-term consequences of intraoperative spillage of bile and gallstones during laparoscopic cholecystectomy. J Gastrointest Surg 1997;1 (1) 85- 91
PubMed
Birkett  DHBirkett  DHBirkett  DHBirkett  DHBirkett  DHBirkett  DH Spilled gallstones after laparoscopic cholecystectomy. Surg Endosc 1998;12 (4) 305- 309
PubMed
Birkett  DHBirkett  DHBirkett  DH Peritoneal gallstones following laparoscopic cholecystectomy. Surg Endosc 2004;18 (8) 1200- 1207
PubMed
Birkett  DHBirkett  DHBirkett  DHBirkett  DH Intraperitoneal abscess after laparoscopic cholecystectomy. Surg Laparosc Endosc 1992;2 (4) 337- 338
PubMed
Birkett  DHBirkett  DHBirkett  DH The “shuttle” stone collector—a new device for collecting lost gallstones in laparoscopic cholecystectomy. Surg Endosc 1992;6 (2) 84
PubMed
Birkett  DHBirkett  DH Unusual abscess patterns following dropped gallstones during laparoscopic cholecystectomy. Am J Surg 1998;175 (5) 375- 379
PubMed
Birkett  DHBirkett  DHBirkett  DH Spilled gallstones after laparoscopic cholecystectomy. J Laparoendosc Adv Surg Tech A 2002;12 (5) 383- 386
PubMed

Figures

Place holder to copy figure label and caption
Figure 2.

After open debridement of the retroperitoneal abscess and discovery of the retained gallstone, a 5-mm enhancing round artifact (arrow) is noted on the computed tomographic scan.

Graphic Jump Location

Tables

References

Birkett  DH Spilled cells, spilled clips, spilled stones. Surg Endosc 1995;9 (3) 269- 271
PubMed
Birkett  DHBirkett  DH Biliary tract.  In: Townsend CM, Beauchamp  RD, Evers  BM, Mattox  K, eds. Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice.17th ed. Philadelphia, PA: WB Saunders Co; 2004:1612-1614
Birkett  DHBirkett  DHBirkett  DH Complications of therapeutic laparoscopy. Curr Probl Surg 1994;31 (11) 857- 924
PubMed
Birkett  DHBirkett  DHBirkett  DH  et al Is the loss of gallstones during laparoscopic cholecystectomy an underestimated complication? Surg Endosc2000144373374 doi:10.1007/PL00013416
Birkett  DHBirkett  DHBirkett  DHFitzgibbons  RJ  Jr The outcome of unretrieved gallstones in the peritoneal cavity during laparoscopic cholecystectomy: a prospective analysis. Surg Endosc 1999;13 (9) 848- 857
PubMed
Birkett  DHBirkett  DHBirkett  DH  et al.  Long-term consequences of intraoperative spillage of bile and gallstones during laparoscopic cholecystectomy. J Gastrointest Surg 1997;1 (1) 85- 91
PubMed
Birkett  DHBirkett  DHBirkett  DHBirkett  DHBirkett  DHBirkett  DH Spilled gallstones after laparoscopic cholecystectomy. Surg Endosc 1998;12 (4) 305- 309
PubMed
Birkett  DHBirkett  DHBirkett  DH Peritoneal gallstones following laparoscopic cholecystectomy. Surg Endosc 2004;18 (8) 1200- 1207
PubMed
Birkett  DHBirkett  DHBirkett  DHBirkett  DH Intraperitoneal abscess after laparoscopic cholecystectomy. Surg Laparosc Endosc 1992;2 (4) 337- 338
PubMed
Birkett  DHBirkett  DHBirkett  DH The “shuttle” stone collector—a new device for collecting lost gallstones in laparoscopic cholecystectomy. Surg Endosc 1992;6 (2) 84
PubMed
Birkett  DHBirkett  DH Unusual abscess patterns following dropped gallstones during laparoscopic cholecystectomy. Am J Surg 1998;175 (5) 375- 379
PubMed
Birkett  DHBirkett  DHBirkett  DH Spilled gallstones after laparoscopic cholecystectomy. J Laparoendosc Adv Surg Tech A 2002;12 (5) 383- 386
PubMed

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