Symptoms are related to the location of the heterotopic tissue. The majority of heterotopic pancreatic tissue is found in the upper gastrointestinal tract. Therefore, common signs and symptoms include epigastric pain, weight loss, hematemesis, nausea and vomiting, and jaundice.3,4,6,7 Benign pathological changes occur in the heterotopic tissue at a similar rate to that of normal pancreas. Pancreatitis, pseudocyst formation, and abnormal hormone secretion have been reported.3 Malignant changes, namely adenocarcinoma, cystadenomas, anaplastic carcinomas, and islet cell adenomas, have also been reported.3,4 Approximately 50% of lesions are symptomatic: symptoms sometimes seem to regress spontaneously, or other causes are found for the symptoms. Reports indicate a 60% success rate of relief of symptoms with surgical resection.3,4 The true incidence of heterotopic pancreas is not known, and most lesions are likely incidental findings without associated signs or symptoms.