During recent years the subject of transplantation of bone has occupied an important place in the literature and has been the text of many practical as well as experimental papers. It is agreed and accepted by the majority of investigators that a live piece of bone from the same individual, with its periosteum and endosteum intact, is the most satisfactory tissue and offers the greatest possibility of successful transplantation. But there are many problems connected with bone transplantation, both from the scientific and the practical standpoint, that are unsolved and disputed. One of these, which will be considered in this paper, is that which is concerned with the part played by function and its influence over the viability of transplanted bone.
If we direct our attention to the physiology of the animal body many instances of the influence of function may be seen. In general, with a maximum of function,