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Arch Surg. 1924;8(2):557-587. doi:10.1001/archsurg.1924.01120050098005.
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An animal or a man who has first been exhausted by exertion, emotion, hemorrhage, asphyxia, anesthesia or loss of sleep succumbs more readily to infection, and an animal or a man exhausted by infection succumbs more readily to trauma, emotion, anesthesia, exertion, loss of sleep, etc. It becomes of value, therefore, to determine whether the exhaustion which is one of the phenomena of either an acute or a chronic infection is essentially different from exhaustion from other causes—emotion, exertion, physical trauma, insomnia.

In an attempt to answer this query, the following studies were made.


I. The Histologic Effect of Bacteria cr of Bacterial Toxins  Nichols, in 1899, Marinesco and other observers have demonstrated the presence of histologic changes in the central nervous system after death from typhoid fever or other diseases of infectious origin; and in inoculated animals. As in the preceding sections of these studies, however,


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