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Arch Surg. 1925;11(1):124-135. doi:10.1001/archsurg.1925.01120130133008.
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About two years ago1 I presented, as concisely as I could, evidence that, of all the suggested causes of cancer, irritation had best stood the tests of clinical observation, statistical study and experimental research. Facts published since that time have brought forward no conclusive controverting evidence, and much that has appeared supports the contention then advanced. Among the data then presented I briefly referred to: chimneysweeps' cancer; smokers' cancer; betel-nut chewers' cancer; soot cancer; pitch-workers' cancer; tar cancer; charcoal-burners' cancer; anthracene cancer; anilin dye cancer; grease-workers' cancer; arsenic cancer; buccal cancers due to dental irritation, faulty dentures, etc.; roentgen-ray cancer; sheep-dip cancer; cancers arising on occupation dermatoses, and on tuberculous, blastomycetic, leptothritic, syphilitic and other chronic irritative processes; experimental cancer, including malignancy induced by tar and tar products and by parasites; cancer associated with bilharziasis; scar sarcomas; keloid; irritation neuromas; cancers following burns; solar influences in the production of


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