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Arch Surg. 1927;14(4):868-890. doi:10.1001/archsurg.1927.01130160077004.
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The purpose of this article is to present the results of the application of a method of defense against the spread of infection in a carbuncle. Carbuncles have been treated by such methods as hyperemia, injection of antiseptics into their centers, ointments, vaccines, roentgen-ray therapy, and conservative and radical surgery, but extensive scarring, lengthy convalescence and the frequency of complicating sepsis or metastatic pus foci accompanying these methods warrant a consideration of any method that may prevent these conditions. To aid healing and to preclude as far as possible the occurrence of septic complications, two factors are essential, first, the least possible trauma to tissue, and, second, the mobilization of the natural forces of defense.

Within the last eighteen years attempts have been made to use whole blood or its constituents locally to combat infection. In 1908, Mueller and Peiser1 injected the patient's defibrinated blood into nonprogressive pyogenic abscesses.


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