Arch Surg. 1927;15(1):89-101. doi:10.1001/archsurg.1927.01130190092007.
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In former papers I have reviewed evidence as to the manner of the transport of calcium salts in the blood stream and their deposition in bone and in calcified areas. The deposition of calcium in bone is in an extremely fine form and in such a manner that from appearances alone it might be interpreted according to the bias of the observer, either as a secretory phenomenon of the osteoblasts and bone cells or as a precipitation phenomenon. Correlated with physiologic evidence, however, the balance of proof is in favor of the secretory view. The object of this investigation, was to learn whether such was also the case in areas of calcification. In this paper I shall review the information I have obtained by the examination and study of various calcified areas, and shall discuss the conclusions to be made from the facts presented.

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