Experimental observations made by one of us (H. B. B.)1 on the effect of the injection of absolute alcohol into the thyroid gland showed a local coagulation necrosis, the extent of which varied directly with the amount of alcohol injected. No general effect was observed. The experiments warranted the conclusion that the injection of absolute alcohol in suitable quantity in cases of disease of the thyroid is a safe and legitimate method. Following this conclusion, we have used this method of treatment in severe hyperthyroidism, and in this paper we report the results.
The use of multiple more or less minor operative procedures in preparation for subtotal thyroidectomy in severe cases of hyperthyroidism is well recognized. Though the use of compound solution of iodine as advocated by Plummer2 has made it possible to convert many cases of exophthalmic goiter from poor risks to the class of fair risks