To the future understanding of malignancy, present day medicine has made its major contributions in the form of analyses of these conditions into clinical entities; and there has been much of therapeutic advantage in the earlier diagnoses thus made possible. In regard to multiple tumors of the bone, much remains to be accomplished in this direction by a compilation of a more complete series of cases thoroughly studied both clinically and pathologically.
In the present article, multiple myeloma has been selected for discussion from among the multiple tumors of the bone. To the group of thirteen cases (comprising our own series) has been added an analysis of all available cases reported in the literature since 1848—in all, a series of 425 cases. Our work is based largely on the material placed at our disposal by Dr. Joseph C. Bloodgood, in the surgical pathological laboratory at the Johns Hopkins Hospital.