Since Sandström's discovery of the external parathyroids in 1880, the parathyroid glands have been discussed extensively.
There are two schools of thought, one being that these glands influence calcium metabolism, and the other that they exert a detoxicating effect on guanidin bodies. The balance of opinion seems to favor the former, and in 1925, definite evidence as to their influence on calcium metabolism was established by Collip,1 and by Collip, Clark and Scott.2
While engaged in an attempt to produce by means of partial parathyroidectomies a condition in the bones of experimental animals analogous to idiopathic osteopsathyrosis in man, it occurred to me that it would be interesting to note the effect of parathyroidectomy, partial or complete, on the healing of fractures.
Morel3 (1909-1910) working with cats, and Canal (1919) working with rats, asserted that removal of the parathyroids causes a delay in the healing of fractures.