Drainage of the total external secretion of the pancreas, as already reported in a previous communication,1 leads to increasingly severe vomiting in a few days, and, in about a week, to a fatal outcome. In the attempt to explain these symptoms of gastric irritability, a number of observations were made. The contents of the stomach were examined in most of the animals, and the behavior of gastric acidity was studied in a special way. The results will be presented in detail. They have suggested among other things that a reciprocal relationship exists between the alkaline pancreatic juice and the acid secretion of the stomach.
One aspect of this relationship has long been known, and the data herein contained adds further proof, that is, that the acid gastric juice, passed into the duodenum, is the normal stimulus of pancreatic secretion. Its discovery by Dolinsky2 in Pavlov's laboratory has been